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    Mbip MAP3K12 binding inhibitory protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mbipprovided by RGD
    Official Full Name
    MAP3K12 binding inhibitory protein 1provided by RGD
    Primary source
    RGD:1306310
    See related
    EnsemblRapid:ENSRNOG00000008610 AllianceGenome:RGD:1306310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and protein kinase inhibitor activity. Predicted to be involved in several processes, including positive regulation of JNK cascade; regulation of gene expression; and regulation of tubulin deacetylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ATAC complex. Predicted to be active in cytosol. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 204.7), Thymus (RPKM 62.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mbip in Genome Data Viewer
    Location:
    6q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79543223..79560476, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (73808133..73825394, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (77226439..77243696, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351238 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120103538 Neighboring gene uncharacterized LOC134479387 Neighboring gene uncharacterized LOC134479388 Neighboring gene uncharacterized LOC102551688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
    2. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
    3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    4. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article
    5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAP3K12-binding inhibitory protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108712.3 → NP_001102182.2  MAP3K12-binding inhibitory protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      B2RZ10

    2. NM_001399696.1 → NP_001386625.1  MAP3K12-binding inhibitory protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBN3, B2RZ10
      Related
      ENSRNOP00000011419.7, ENSRNOT00000011419.7

    3. NM_001399697.1 → NP_001386626.1  MAP3K12-binding inhibitory protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      B2RZ10

    4. NM_001399698.1 → NP_001386627.1  MAP3K12-binding inhibitory protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      B2RZ10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      79543223..79560476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262114.1 → XP_063118184.1  MAP3K12-binding inhibitory protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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