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    Myo1f myosin IF [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo1fprovided by RGD
    Official Full Name
    myosin IFprovided by RGD
    Primary source
    RGD:1309750
    See related
    EnsemblRapid:ENSRNOG00000008409 AllianceGenome:RGD:1309750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; neutrophil degranulation; and positive regulation of neutrophil migration. Predicted to be located in cortical actin cytoskeleton and cytosol. Predicted to be part of filamentous actin. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Orthologous to human MYO1F (myosin IF). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 216.4), Lung (RPKM 160.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo1f in Genome Data Viewer
    Location:
    7q11-q13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15065530..15116087)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14363340..14413911)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18440742..18491448)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549242 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 10 Neighboring gene uncharacterized LOC120093540 Neighboring gene BAF nuclear assembly factor 1, pseudogene 1 Neighboring gene zinc finger protein 414 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of cell adhesion and motility in the immune system by Myo1f. Kim SV, et al. Science, 2006 Oct 6. PMID 17023661
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-If
    Names
    myosin-If

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108076.2 → NP_001101546.1  unconventional myosin-If

      See identical proteins and their annotated locations for NP_001101546.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AWI1, A6KQG6, D4A7X9
      Related
      ENSRNOP00000011513.5, ENSRNOT00000011513.7
      Conserved Domains (4) summary
      cd11827
      Location:1045 → 1097
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:12 → 690
      MYSc; Myosin. Large ATPases
      cd01378
      Location:31 → 677
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:717 → 899
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15065530..15116087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079030.2 → XP_038934958.1  unconventional myosin-If isoform X1

      UniProtKB/TrEMBL
      A0A8I6AWI1
      Conserved Domains (4) summary
      cd11827
      Location:922 → 974
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      PHA03247
      Location:797 → 920
      PHA03247; large tegument protein UL36; Provisional
      cd01378
      Location:1 → 554
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:594 → 792
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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