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    Loxl3 lysyl oxidase-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312478, updated on 9-Dec-2024

    Summary

    Official Symbol
    Loxl3provided by RGD
    Official Full Name
    lysyl oxidase-like 3provided by RGD
    Primary source
    RGD:1311011
    See related
    EnsemblRapid:ENSRNOG00000061373 AllianceGenome:RGD:1311011
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fibronectin binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; fibronectin fibril organization; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 32.1), Heart (RPKM 31.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Loxl3 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117098358..117114673)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115540640..115556958)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113866782..113883713)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene meiosis 1 associated protein Neighboring gene uncharacterized LOC120102319 Neighboring gene docking protein 1 Neighboring gene HtrA serine peptidase 2 Neighboring gene AUP1, lipid droplet regulating VLDL assembly factor Neighboring gene DEAQ box RNA-dependent ATPase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding  
    enables fibronectin binding  
    enables protein-lysine 6-oxidase activity  
    enables protein-lysine 6-oxidase activity  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix  
    located_in cytoplasm  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in nucleus  

    General protein information

    Preferred Names
    lysyl oxidase homolog 3
    NP_001101336.1
    XP_038963514.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107866.2NP_001101336.1  lysyl oxidase homolog 3 precursor

      See identical proteins and their annotated locations for NP_001101336.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAI6, D3ZP82
      Related
      ENSRNOP00000109267.1, ENSRNOT00000148185.1
      Conserved Domains (2) summary
      smart00202
      Location:308408
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:531730
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117098358..117114673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107586.2XP_038963514.2  lysyl oxidase homolog 3 isoform X1

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