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    Cav2 caveolin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363425, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cav2provided by RGD
    Official Full Name
    caveolin 2provided by RGD
    Primary source
    RGD:620348
    See related
    AllianceGenome:RGD:620348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity; phosphoprotein binding activity; and syntaxin binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of endothelial cell proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including caveola; lipid droplet; and nuclear inner membrane. Part of protein-containing complex. Biomarker of high grade glioma and obesity. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 1125.0), Heart (RPKM 413.6) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Cav2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (46582681..46590058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (45616766..45624144)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (44573264..44580640)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene testin LIM domain protein Neighboring gene uncharacterized LOC102550644 Neighboring gene caveolin 1 Neighboring gene uncharacterized LOC103692063

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC72322

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding  
    enables D1 dopamine receptor binding PubMed 
    enables SNARE binding PubMed 
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables phosphoprotein binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables syntaxin binding PubMed 
    Items 1 - 25 of 64
    Process Evidence Code Pubs
    involved_in basement membrane organization  
    acts_upstream_of_or_within basement membrane organization  
    involved_in caveola assembly  
    involved_in caveola assembly  
    involved_in caveola assembly  
    involved_in caveola assembly PubMed 
    involved_in cell differentiation  
    acts_upstream_of cell population proliferation  
    involved_in chemical synaptic transmission PubMed 
    involved_in endoplasmic reticulum organization  
    acts_upstream_of_or_within endoplasmic reticulum organization  
    involved_in endoplasmic reticulum organization  
    involved_in endothelial cell proliferation  
    acts_upstream_of endothelial cell proliferation  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in mitochondrion organization  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of endothelial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of skeletal muscle cell proliferation  
    acts_upstream_of_or_within negative regulation of skeletal muscle cell proliferation  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation by host of viral process  
    involved_in positive regulation by host of viral process  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of dopamine receptor signaling pathway  
    involved_in positive regulation of dopamine receptor signaling pathway  
    involved_in positive regulation of dopamine receptor signaling pathway PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of protein localization to nucleus PubMed 
    involved_in receptor-mediated endocytosis of virus by host cell  
    involved_in receptor-mediated endocytosis of virus by host cell  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of mitotic nuclear division  
    involved_in regulation of mitotic nuclear division  
    involved_in skeletal muscle cell proliferation  
    acts_upstream_of skeletal muscle cell proliferation  
    involved_in skeletal muscle fiber development  
    acts_upstream_of_or_within skeletal muscle fiber development  
    involved_in skeletal muscle fiber development  
    involved_in transforming growth factor beta receptor signaling pathway  
    acts_upstream_of transforming growth factor beta receptor signaling pathway  
    involved_in vesicle docking  
    involved_in vesicle docking  
    involved_in vesicle docking PubMed 
    involved_in vesicle fusion  
    involved_in vesicle fusion  
    involved_in vesicle fusion PubMed 
    involved_in vesicle organization  
    involved_in viral release from host cell  
    involved_in viral release from host cell  
    Items 1 - 25 of 64
    Items 1 - 20 of 36
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in Golgi membrane  
    located_in acrosomal membrane  
    located_in acrosomal membrane  
    located_in caveola PubMed 
    located_in caveola  
    located_in caveola PubMed 
    part_of caveolar macromolecular signaling complex  
    part_of caveolar macromolecular signaling complex  
    located_in cell surface PubMed 
    is_active_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    colocalizes_with focal adhesion  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in lipid droplet PubMed 
    located_in membrane  
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in nuclear envelope PubMed 
    located_in nuclear inner membrane PubMed 
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane raft  
    located_in plasma membrane raft PubMed 
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    colocalizes_with sarcolemma  
    located_in synapse  
    located_in transport vesicle  
    located_in transport vesicle  
    Items 1 - 20 of 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131914.3NP_571989.3  caveolin-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q2IBC5, Q6P6R8, Q8VIK7
      UniProtKB/TrEMBL
      A0A0A0MXU8, A6IE19
      Conserved Domains (1) summary
      pfam01146
      Location:39160
      Caveolin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      46582681..46590058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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