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    Aanat aralkylamine N-acetyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25120, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aanatprovided by RGD
    Official Full Name
    aralkylamine N-acetyltransferaseprovided by RGD
    Primary source
    RGD:2006
    See related
    EnsemblRapid:ENSRNOG00000011182 AllianceGenome:RGD:2006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nat4; AA-NAT
    Summary
    The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in Spleen (RPKM 2.3), Testes (RPKM 2.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Aanat in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102323647..102330639)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101827072..101831805)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105568091..105572407)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene rhomboid 5 homolog 2 Neighboring gene cytoglobin Neighboring gene photoreceptor disc component

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation  
    involved_in N-terminal protein amino acid acetylation  
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in circadian rhythm  
    involved_in circadian rhythm PubMed 
    involved_in circadian rhythm  
    involved_in entrainment of circadian clock by photoperiod PubMed 
    involved_in melatonin biosynthetic process  
    involved_in melatonin biosynthetic process  
    involved_in melatonin biosynthetic process  
    involved_in melatonin biosynthetic process  
    involved_in melatonin biosynthetic process PubMed 
    involved_in photoperiodism PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to calcium ion PubMed 
    involved_in response to copper ion PubMed 
    involved_in response to corticosterone PubMed 
    involved_in response to cytokine PubMed 
    involved_in response to insulin PubMed 
    involved_in response to light stimulus  
    involved_in response to light stimulus PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide PubMed 
    involved_in response to prostaglandin E PubMed 
    involved_in response to zinc ion PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    serotonin N-acetyltransferase
    Names
    Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)
    Seretonin N-acetyltransferase
    arylakylamine N-acetyltransferase
    arylalkylamine N-acetyltransferase
    serotonin acetylase
    NP_036950.1
    XP_006247854.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012818.2NP_036950.1  serotonin N-acetyltransferase

      See identical proteins and their annotated locations for NP_036950.1

      Status: VALIDATED

      Source sequence(s)
      U38306
      UniProtKB/Swiss-Prot
      Q4JL74, Q64553, Q64666
      UniProtKB/TrEMBL
      A6HKX7
      Related
      ENSRNOP00000015221.2, ENSRNOT00000015221.6
      Conserved Domains (1) summary
      cl17182
      Location:31181
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102323647..102330639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247792.4XP_006247854.1  serotonin N-acetyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006247854.1

      UniProtKB/Swiss-Prot
      Q4JL74, Q64553, Q64666
      UniProtKB/TrEMBL
      A6HKX7
      Conserved Domains (1) summary
      cl17182
      Location:31181
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
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