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    Rnf112 ring finger protein 112 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24916, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf112provided by RGD
    Official Full Name
    ring finger protein 112provided by RGD
    Primary source
    RGD:3986
    See related
    EnsemblRapid:ENSRNOG00000002364 AllianceGenome:RGD:3986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BFP; Bfb; Zfp179; Znf179
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including embryonic brain development; protein autoubiquitination; and protein homooligomerization. Predicted to act upstream of or within G1 to G0 transition involved in cell differentiation; positive regulation of glial cell differentiation; and positive regulation of neuron differentiation. Predicted to be located in several cellular components, including cytoplasmic vesicle; nuclear body; and postsynaptic density. Orthologous to human RNF112 (ring finger protein 112). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 187.5), Lung (RPKM 11.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Rnf112 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46620602..46655745, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46121146..46126691, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47719034..47726050, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 47 member 1 Neighboring gene uncharacterized LOC134480695 Neighboring gene transfer RNA tryptophan (anticodon CCA) 2 Neighboring gene uncharacterized LOC134480801 Neighboring gene uncharacterized LOC120095256 Neighboring gene microfibril associated protein 4 Neighboring gene mitogen-activated protein kinase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in G1 to G0 transition involved in cell differentiation  
    acts_upstream_of_or_within G1 to G0 transition involved in cell differentiation  
    involved_in embryonic brain development  
    involved_in embryonic brain development  
    involved_in embryonic brain development  
    involved_in endoplasmic reticulum organization  
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    involved_in positive regulation of glial cell differentiation  
    acts_upstream_of_or_within positive regulation of glial cell differentiation  
    involved_in positive regulation of neuron differentiation  
    acts_upstream_of_or_within positive regulation of neuron differentiation  
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein homooligomerization  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in response to hydroperoxide  
    involved_in response to hydroperoxide  
    involved_in response to hydroperoxide  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in cell body  
    located_in cell body  
    located_in cell body  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endosome  
    located_in endosome  
    located_in endosome  
    located_in membrane  
    located_in neuron projection  
    located_in nuclear body  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon  
    located_in postsynaptic density  
    located_in postsynaptic density  
    located_in postsynaptic density  
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    RING finger protein 112
    Names
    brain finger protein
    zinc finger protein 179
    NP_619516.1
    XP_063124516.1
    XP_063124517.1
    XP_063124518.1
    XP_063124519.1
    XP_063124520.1
    XP_063124521.1
    XP_063124522.1
    XP_063124523.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430037.1NP_001416966.1  RING finger protein 112 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HF79
    2. NM_138613.3NP_619516.1  RING finger protein 112 isoform 1

      See identical proteins and their annotated locations for NP_619516.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O70418
      UniProtKB/TrEMBL
      A6HF79
      Conserved Domains (2) summary
      cd01851
      Location:163394
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd00162
      Location:56101
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46620602..46655745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268446.1XP_063124516.1  RING finger protein 112 isoform X1

    2. XM_063268447.1XP_063124517.1  RING finger protein 112 isoform X2

    3. XM_063268449.1XP_063124519.1  RING finger protein 112 isoform X4

    4. XM_063268450.1XP_063124520.1  RING finger protein 112 isoform X5

    5. XM_063268448.1XP_063124518.1  RING finger protein 112 isoform X3

      Related
      ENSRNOP00000003228.6, ENSRNOT00000003228.7
    6. XM_063268451.1XP_063124521.1  RING finger protein 112 isoform X6

      UniProtKB/TrEMBL
      A6HF79
    7. XM_063268453.1XP_063124523.1  RING finger protein 112 isoform X8

    8. XM_063268452.1XP_063124522.1  RING finger protein 112 isoform X7

      UniProtKB/TrEMBL
      A0A0H2UHA8, A6HF79
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