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    Greb1l GREB1 like retinoic acid receptor coactivator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498819, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Greb1lprovided by RGD
    Official Full Name
    GREB1 like retinoic acid receptor coactivatorprovided by RGD
    Primary source
    RGD:1562371
    See related
    EnsemblRapid:ENSRNOG00000023492 AllianceGenome:RGD:1562371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562371
    Summary
    Predicted to be involved in kidney development and morphogenesis of an epithelium. Predicted to act upstream of or within several processes, including kidney development; paramesonephric duct development; and reproductive structure development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 80 and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 38.0), Kidney (RPKM 33.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Greb1l in Genome Data Viewer
    Location:
    18p13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1665468..1902291)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1392330..1629483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1537315..1784260)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like Neighboring gene ribosomal protein L36A, pseudogene 10 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 2 Neighboring gene heat shock protein family D (Hsp60) member 1 like 1 Neighboring gene protein RCC2-like Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene ATP synthase membrane subunit G like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
    2. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. De Tomasi L, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100091, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac ventricle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male genitalia development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesonephric duct development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within paramesonephric duct development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within uterus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GREB1 like retinoic acid receptor coactivator; GREB1-like protein
    Names
    growth regulation by estrogen in breast cancer 1 like
    growth regulation by estrogen in breast cancer-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432470.1 → NP_001419399.1  GREB1 like retinoic acid receptor coactivator

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KNE1, F1LTR0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1665468..1902291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097272.2 → XP_038953200.1  GREB1-like protein isoform X3

      UniProtKB/TrEMBL
      A6KNE1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1888
      GREB1; Gene regulated by oestrogen in breast cancer

    2. XM_039097267.2 → XP_038953195.1  GREB1-like protein isoform X1

      UniProtKB/TrEMBL
      A6KNE1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer

    3. XM_039097268.2 → XP_038953196.1  GREB1-like protein isoform X1

      UniProtKB/TrEMBL
      A6KNE1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer

    4. XM_039097265.2 → XP_038953193.1  GREB1-like protein isoform X1

      UniProtKB/TrEMBL
      A6KNE1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer

    5. XM_039097270.2 → XP_038953198.1  GREB1-like protein isoform X2

      Related
      ENSRNOP00000109265.1, ENSRNOT00000156299.1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1912
      GREB1; Gene regulated by oestrogen in breast cancer

    6. XM_039097269.2 → XP_038953197.1  GREB1-like protein isoform X1

      UniProtKB/TrEMBL
      A6KNE1
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer

    7. XM_039097266.2 → XP_038953194.1  GREB1-like protein isoform X1

      UniProtKB/TrEMBL
      A6KNE1
      Related
      ENSRNOP00000029000.8, ENSRNOT00000033468.8
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1955
      GREB1; Gene regulated by oestrogen in breast cancer
    Nucleotide Protein Strain
    Heading Accession and Version

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