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    Spag16 sperm associated antigen 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spag16provided by RGD
    Official Full Name
    sperm associated antigen 16provided by RGD
    Primary source
    RGD:1565062
    See related
    EnsemblRapid:ENSRNOG00000054475 EnsemblRapid:ENSRNOG00000075101 AllianceGenome:RGD:1565062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565062
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in axoneme assembly. Predicted to act upstream of or within cerebrospinal fluid circulation; mucociliary clearance; and sperm axoneme assembly. Predicted to be located in axonemal central apparatus and sperm flagellum. Orthologous to human SPAG16 (sperm associated antigen 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 137.6) See more
    Orthologs
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    Genomic context

    See Spag16 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (78782596..79702265)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (71333005..72252772)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (77027626..77833476)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 2 Neighboring gene uncharacterized LOC134480292 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480385 Neighboring gene phosphoglycerate kinase 1-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 1 Neighboring gene tubulin, beta 4B class IVb, pseudogene 4 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene von Willebrand factor C domain containing 2 like Neighboring gene uncharacterized LOC120094698 Neighboring gene BRCA1 associated RING domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC187457

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axoneme assembly  
    involved_in axoneme assembly  
    acts_upstream_of_or_within cerebrospinal fluid circulation  
    involved_in cilium assembly  
    acts_upstream_of_or_within mucociliary clearance  
    acts_upstream_of_or_within sperm axoneme assembly  
    Component Evidence Code Pubs
    is_active_in axonemal central apparatus  
    located_in axonemal central apparatus  
    located_in axoneme  
    located_in extracellular region  
    located_in sperm flagellum  

    General protein information

    Preferred Names
    sperm-associated antigen 16 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134728.1 → NP_001128200.1  sperm-associated antigen 16 protein isoform 2

      See identical proteins and their annotated locations for NP_001128200.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158602
      UniProtKB/TrEMBL
      B0BMX7
      Related
      ENSRNOP00000063278.5, ENSRNOT00000068450.5
      Conserved Domains (3) summary
      COG2319
      Location:20 → 309
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:23 → 309
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:34 → 71
      7WD40; WD40 repeat [structural motif]
    2. NM_001401616.1 → NP_001388545.1  sperm-associated antigen 16 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F1M3E0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      78782596..79702265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267621.1 → XP_063123691.1  sperm-associated antigen 16 protein isoform X1

    2. XM_039084101.2 → XP_038940029.1  sperm-associated antigen 16 protein isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:354 → 618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:365 → 402
      7WD40; WD40 repeat [structural motif]
    3. XM_039084103.2 → XP_038940031.1  sperm-associated antigen 16 protein isoform X4

      Conserved Domains (2) summary
      cd00200
      Location:358 → 578
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:365 → 402
      7WD40; WD40 repeat [structural motif]
    4. XM_039084102.2 → XP_038940030.1  sperm-associated antigen 16 protein isoform X3

      Conserved Domains (2) summary
      cd00200
      Location:358 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:402 → 438
      7WD40; WD40 repeat [structural motif]
    5. XM_039084104.2 → XP_038940032.1  sperm-associated antigen 16 protein isoform X5

      Conserved Domains (2) summary
      cd00200
      Location:358 → 519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:366 → 402
      7WD40; WD40 repeat [structural motif]
    6. XM_063267623.1 → XP_063123693.1  sperm-associated antigen 16 protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6AFW5
    7. XM_063267624.1 → XP_063123694.1  sperm-associated antigen 16 protein isoform X7

    RNA

    1. XR_005488954.2 RNA Sequence

    2. XR_005488955.2 RNA Sequence

      Related
      ENSRNOT00000089203.3
    3. XR_010054628.1 RNA Sequence

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