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    Mboat7 membrane bound O-acyltransferase domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308309, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mboat7provided by RGD
    Official Full Name
    membrane bound O-acyltransferase domain containing 7provided by RGD
    Primary source
    RGD:1306945
    See related
    EnsemblRapid:ENSRNOG00000052600 AllianceGenome:RGD:1306945
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Leng4; Mboat7l1; RGD1306945
    Summary
    Predicted to enable O-acyltransferase activity and lysophospholipid acyltransferase activity. Predicted to be involved in glycerophospholipid metabolic process and regulation of triglyceride metabolic process. Predicted to act upstream of or within layer formation in cerebral cortex; phosphatidylinositol metabolic process; and ventricular system development. Predicted to be located in endoplasmic reticulum; membrane; and mitochondria-associated endoplasmic reticulum membrane contact site. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: GeneIDs 103689982 and 308309 are annotated independently on Rnor_6.0 but may be redundant loci. [06 Feb 2015]
    Expression
    Biased expression in Brain (RPKM 104.9), Adrenal (RPKM 66.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mboat7 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74440618..74454896)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65525206..65539538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64100159..64114437)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene paired Ig-like receptor B Neighboring gene ribosomal protein S9 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene transmembrane channel-like 4 Neighboring gene leukocyte receptor cluster member 1 Neighboring gene CCR4-NOT transcription complex, subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC189503

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in membrane  
    located_in membrane  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site  

    General protein information

    Preferred Names
    lysophospholipid acyltransferase 7
    Names
    leukocyte receptor cluster (LRC) member 4
    membrane bound O-acyltransferase domain containing 7-like 1
    NP_001128450.2
    XP_038966897.1
    XP_063144742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134978.2NP_001128450.2  lysophospholipid acyltransferase 7

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KS21, B5DFK0, G3V7N6
      Related
      ENSRNOP00000069855.1, ENSRNOT00000090873.3
      Conserved Domains (1) summary
      cl00738
      Location:8431
      MBOAT; membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74440618..74454896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110969.2XP_038966897.1  lysophospholipid acyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      A6KS21, B5DFK0, G3V7N6
      Conserved Domains (1) summary
      cl00738
      Location:8431
      MBOAT; membrane-bound O-acyltransferase family
    2. XM_063288672.1XP_063144742.1  lysophospholipid acyltransferase 7 isoform X2

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