Fndc1 fibronectin type III domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fndc1provided by RGD
Official Full Name: fibronectin type III domain containing 1provided by RGD
Primary source: RGD:1310640
See related: EnsemblRapid:ENSRNOG00000030210 AllianceGenome:RGD:1310640
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Acts upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in cell-cell junction; mitochondrial membrane; and plasma membrane. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 96.5), Heart (RPKM 66.5) and 6 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (49686856..49769263)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47281839..47364247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (47605211..47687499)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in Fndc1 gene is associated with Hypertension.
Title: Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension.
AGS8 is required for hypoxia-induced apoptosis of ardiomyocytes.
Title: Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).
Activator of G protein signaling 8 (AGS8, KIAA1866) has been isolated from a rat heart model of repetitive transient ischemia. AGS8 appears to promote G protein signaling by a mechanism that involves direct interaction with G-protein betagamma [AGS8]
Title: Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH140011 (e-PCR)
- UniSTS:222093

AW529829 (e-PCR)
- UniSTS:261291

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: fibronectin type III domain-containing protein 1

Names: activator of G-protein signaling 8; fibronectin type III domain containing 1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038615.2 → NP_001033704.2 fibronectin type III domain-containing protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q2Q0I9

UniProtKB/TrEMBL

A0A128DZ42

Related

ENSRNOP00000029878.4, ENSRNOT00000034842.6
NM_001412560.1 → NP_001399489.1 fibronectin type III domain-containing protein 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K4G5, A0A8I5ZT63

Related

ENSRNOP00000073034.1, ENSRNOT00000089458.3