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    Skor1 SKI family transcriptional corepressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skor1provided by RGD
    Official Full Name
    SKI family transcriptional corepressor 1provided by RGD
    Primary source
    RGD:1307687
    See related
    EnsemblRapid:ENSRNOG00000013959 AllianceGenome:RGD:1307687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lbxcor1; RGD1307687
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in dendrite and neuronal cell body. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 5.9), Testes (RPKM 5.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Skor1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (72494554..72505127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (63599153..63609727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (68029930..68040504, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A , pseudogene 16 Neighboring gene U6 spliceosomal RNA Neighboring gene mitogen activated protein kinase kinase 5 Neighboring gene uncharacterized LOC134480190 Neighboring gene uncharacterized LOC102547003 Neighboring gene similar to human chromosome 15 open reading frame 61

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. Arndt S, et al. Mol Cell Neurosci, 2007 Apr. PMID 17292623
    2. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. Mizuhara E, et al. J Biol Chem, 2005 Feb 4. PMID 15528197
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SKI family transcriptional corepressor 1
    Names
    ladybird homeobox 1 homolog corepressor 1
    ladybird homeobox corepressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376952.1 → NP_001363881.1  SKI family transcriptional corepressor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P84551
      Related
      ENSRNOP00000018756.5, ENSRNOT00000018756.6
      Conserved Domains (3) summary
      smart01046
      Location:180 → 272
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:75 → 168
      Ski_Sno; SKI/SNO/DAC family
      pfam15236
      Location:850 → 934
      CCDC66; Coiled-coil domain-containing protein 66

    2. NM_001376953.1 → NP_001363882.1  SKI family transcriptional corepressor 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000008
      Conserved Domains (3) summary
      smart01046
      Location:141 → 233
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:36 → 129
      Ski_Sno; SKI/SNO/DAC family
      pfam15236
      Location:811 → 895
      CCDC66; Coiled-coil domain-containing protein 66

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      72494554..72505127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84551.1 GenPept UniProtKB/Swiss-Prot:P84551

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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