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    Ccna2 cyclin A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114494, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccna2provided by RGD
    Official Full Name
    cyclin A2provided by RGD
    Primary source
    RGD:621059
    See related
    EnsemblRapid:ENSRNOG00000015423 AllianceGenome:RGD:621059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to peptide hormone stimulus. Predicted to be located in cytosol; nucleoplasm; and pronucleus. Predicted to be part of cyclin A2-CDK1 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Biomarker of myocardial infarction. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 275.4), Spleen (RPKM 179.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccna2 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121355363..121361762, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119427239..119433645, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123274727..123282266, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene transient receptor potential cation channel, subfamily C, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC156527

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in Ras protein signal transduction  
    involved_in animal organ regeneration PubMed 
    involved_in cell cycle G1/S phase transition  
    involved_in cell division  
    involved_in cellular response to cocaine PubMed 
    involved_in cellular response to estradiol stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to leptin stimulus PubMed 
    involved_in cellular response to luteinizing hormone stimulus PubMed 
    involved_in cellular response to nitric oxide PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in cochlea development PubMed 
    involved_in positive regulation of DNA biosynthetic process PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of fibroblast proliferation PubMed 
    involved_in post-translational protein modification  
    involved_in regulation of DNA replication  
    involved_in response to estradiol PubMed 
    involved_in response to glucagon PubMed 
    Component Evidence Code Pubs
    part_of cyclin A2-CDK1 complex  
    part_of cyclin A2-CDK2 complex  
    part_of cyclin A2-CDK2 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in female pronucleus  
    located_in male pronucleus  
    is_active_in microtubule organizing center  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053702.3NP_446154.3  cyclin-A2

      See identical proteins and their annotated locations for NP_446154.3

      Status: VALIDATED

      Source sequence(s)
      AF367448, CK845133, CV114678, DY317814, DY551463
      UniProtKB/TrEMBL
      A0A0G2JVY9, A6IHY4
      Related
      ENSRNOP00000069674.2, ENSRNOT00000079745.3
      Conserved Domains (3) summary
      pfam00134
      Location:167293
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:295413
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:17147
      Cyclin_N2; N-terminal region of cyclin_N

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      121355363..121361762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760903.4XP_008759125.1  cyclin-A2 isoform X2

      Conserved Domains (3) summary
      pfam00134
      Location:194320
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:322440
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:17174
      Cyclin_N2; N-terminal region of cyclin_N
    2. XM_006232266.5XP_006232328.1  cyclin-A2 isoform X1

      UniProtKB/TrEMBL
      G3V802, Q6GX88
      Related
      ENSRNOP00000021156.5, ENSRNOT00000021156.8
      Conserved Domains (2) summary
      pfam00134
      Location:129255
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:257375
      Cyclin_C; Cyclin, C-terminal domain
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