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    Nadk2 NAD kinase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nadk2provided by RGD
    Official Full Name
    NAD kinase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1306809
    See related
    EnsemblRapid:ENSRNOG00000054157 AllianceGenome:RGD:1306809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nadkd1; RGD1306809
    Summary
    Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 598.4), Adrenal (RPKM 340.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nadk2 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (59844854..59886989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58117674..58159815)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58462588..58504735)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485718 Neighboring gene RAN binding protein 3-like Neighboring gene uncharacterized LOC120100736 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene S-phase kinase associated protein 2 Neighboring gene LMBR1 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase. Zhang R. J Cell Physiol, 2015 Aug. PMID 25641397
    2. Identification and characterization of a human mitochondrial NAD kinase. Ohashi K, et al. Nat Commun, 2012. PMID 23212377, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125061

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 2, mitochondrial
    Names
    NAD kinase domain containing 1
    NAD kinase domain-containing protein 1, mitochondrial
    mitochondrial NAD kinase
    NP_001037717.1
    XP_006232076.1
    XP_006232077.1
    XP_006232078.1
    XP_038958668.1
    XP_038958669.1
    XP_063138318.1
    XP_063138319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044252.2 → NP_001037717.1  NAD kinase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001037717.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q1HCL7, Q3B8P3
      UniProtKB/TrEMBL
      A6KGJ0
      Related
      ENSRNOP00000074419.1, ENSRNOT00000083799.3
      Conserved Domains (1) summary
      cl01255
      Location:79 → 301
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      59844854..59886989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232014.4 → XP_006232076.1  NAD kinase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A096MKG5, A0A8I5ZN07
      Related
      ENSRNOP00000074867.2, ENSRNOT00000080618.3
      Conserved Domains (1) summary
      cl01255
      Location:82 → 326
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. XM_006232015.4 → XP_006232077.1  NAD kinase 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQT4, A6KGJ0
      Related
      ENSRNOP00000080674.1, ENSRNOT00000111710.2
      Conserved Domains (1) summary
      cl01255
      Location:82 → 304
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. XM_006232016.5 → XP_006232078.1  NAD kinase 2, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZN07
      Conserved Domains (1) summary
      cl01255
      Location:44 → 273
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. XM_063282248.1 → XP_063138318.1  NAD kinase 2, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A6KGJ0

    5. XM_039102740.2 → XP_038958668.1  NAD kinase 2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN07
      Conserved Domains (1) summary
      cl01255
      Location:49 → 278
      DAGK_cat; Diacylglycerol kinase catalytic domain

    6. XM_039102741.2 → XP_038958669.1  NAD kinase 2, mitochondrial isoform X7

      Conserved Domains (1) summary
      cl01255
      Location:2 → 177
      DAGK_cat; Diacylglycerol kinase catalytic domain

    7. XM_063282249.1 → XP_063138319.1  NAD kinase 2, mitochondrial isoform X6

      Related
      ENSRNOP00000080309.2, ENSRNOT00000118441.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1HCL7.1 GenPept UniProtKB/Swiss-Prot:Q1HCL7

    Gene LinkOut

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