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    Naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa25provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 25, NatB auxiliary subunitprovided by RGD
    Primary source
    RGD:1305685
    See related
    EnsemblRapid:ENSRNOG00000001350 AllianceGenome:RGD:1305685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mdm20; LRRGT00164; RGD1305685
    Summary
    Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Located in cytoplasm. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 105.6), Muscle (RPKM 101.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naa25 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40758909..40811192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35098256..35150498, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40628005..40680421, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene 40S ribosomal protein S27-like Neighboring gene 40S ribosomal protein S20-like Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation. Yasuda K, et al. PLoS One, 2013. PMID 24358196, Free PMC Article
    2. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Ohyama K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22101279
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NatB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Names
    N-terminal acetyltransferase B complex subunit MDM20
    N-terminal acetyltransferase B complex subunit NAA25
    liver regeneration-related protein LRRGT00164
    mitochondrial distribution and morphology protein 20
    natB complex subunit MDM20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413582.1 → NP_001400511.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q6QI44
      UniProtKB/TrEMBL
      A0A0G2K9Q3, A6J1F1
      Related
      ENSRNOP00000075085.2, ENSRNOT00000080418.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40758909..40811192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271535.1 → XP_063127605.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

      UniProtKB/Swiss-Prot
      Q6QI44
      Related
      ENSRNOP00000049175.1, ENSRNOT00000048984.4

    2. XM_039089597.2 → XP_038945525.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

      UniProtKB/TrEMBL
      A6J1F2
      Conserved Domains (2) summary
      sd00006
      Location:47 → 73
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:264 → 553
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

    3. XM_039089598.2 → XP_038945526.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

      UniProtKB/TrEMBL
      A6J1F2
      Conserved Domains (2) summary
      sd00006
      Location:47 → 73
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:264 → 553
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

    RNA

    1. XR_005491649.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047900.1: Suppressed sequence

      Description
      NM_001047900.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QI44.1 GenPept UniProtKB/Swiss-Prot:Q6QI44

    Gene LinkOut

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