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    Sytl3 synaptotagmin-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sytl3provided by RGD
    Official Full Name
    synaptotagmin-like 3provided by RGD
    Primary source
    RGD:1561992
    See related
    EnsemblRapid:ENSRNOG00000018321 AllianceGenome:RGD:1561992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561992
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and neurexin family protein binding activity. Predicted to be involved in exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL3 (synaptotagmin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 53.3), Spleen (RPKM 36.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sytl3 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49300935..49372533)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46896308..46967461)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47216988..47287372)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482652 Neighboring gene transmembrane protein 181 Neighboring gene dynein light chain Tctex-type 1 Neighboring gene uncharacterized LOC120099117 Neighboring gene ezrin Neighboring gene RNA, U6 small nuclear 546

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Fukuda M, et al. Biochem Biophys Res Commun, 2001 Mar. PMID 11243866
    2. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127560.1 → NP_001121032.1  synaptotagmin-like protein 3

      See identical proteins and their annotated locations for NP_001121032.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166706
      UniProtKB/TrEMBL
      B2RYA4
      Conserved Domains (4) summary
      cd04020
      Location:448 → 608
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      pfam13836
      Location:203 → 294
      DUF4195; Domain of unknown function (DUF4195)
      cl14603
      Location:307 → 434
      C2; C2 domain
      cl22851
      Location:60 → 108
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49300935..49372533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270702.1 → XP_063126772.1  synaptotagmin-like protein 3 isoform X2

    2. XM_006227888.5 → XP_006227950.1  synaptotagmin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      E9PU77
      Related
      ENSRNOP00000024967.5, ENSRNOT00000024967.6
      Conserved Domains (4) summary
      cd04020
      Location:449 → 609
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:308 → 435
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    3. XM_017589549.3 → XP_017445038.1  synaptotagmin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      E9PU77
      Conserved Domains (4) summary
      cd04020
      Location:449 → 609
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:308 → 435
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    4. XM_039086870.2 → XP_038942798.1  synaptotagmin-like protein 3 isoform X3

      Conserved Domains (3) summary
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:308 → 435
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    5. XM_039086845.2 → XP_038942773.1  synaptotagmin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      E9PU77
      Related
      ENSRNOP00000108013.1, ENSRNOT00000161748.1
      Conserved Domains (4) summary
      cd04020
      Location:449 → 609
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:308 → 435
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily

    6. XM_039086856.2 → XP_038942784.1  synaptotagmin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      E9PU77
      Conserved Domains (4) summary
      cd04020
      Location:449 → 609
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl28890
      Location:60 → 108
      FYVE_like_SF; FYVE domain like superfamily
      cl14603
      Location:308 → 435
      C2; C2 domain
      cl22851
      Location:14 → 123
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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