Rhag Rh-associated glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rhagprovided by RGD
Full Name: Rh-associated glycoproteinprovided by RGD
Primary source: RGD:61871
See related: EnsemblRapid:ENSRNOG00000050121 AllianceGenome:RGD:61871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rh50
Summary: Predicted to enable several functions, including ankyrin binding activity; carbon dioxide transmembrane transporter activity; and channel activity. Predicted to be involved in several processes, including ammonium transmembrane transport; carbon dioxide transmembrane transport; and methylammonium transmembrane transport. Predicted to act upstream of or within erythrocyte development and multicellular organismal-level iron ion homeostasis. Predicted to be located in membrane. Predicted to be part of ankyrin-1 complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; hemolytic anemia; and overhydrated hereditary stomatocytosis. Orthologous to human RHAG (Rh associated glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 387.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (27566349..27594390, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (20069800..20097836, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (23465190..23493081, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IEA Inferred from Electronic Annotation more info
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables leak channel activity	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables methylammonium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables methylammonium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables methylammonium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in carbon dioxide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylammonium transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in methylammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in methylammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ammonium transporter Rh type A

Names: Rhesus blood group-associated A glycoprotein; Rhesus blood group-associated A glycoprotein-like; erythrocyte membrane glycoprotein Rh50; glycoprotein 50kD; rh family type A glycoprotein; rh type A glycoprotein; rhesus blood group family type A glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.