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    Mgll monoglyceride lipase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29254, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mgllprovided by RGD
    Official Full Name
    monoglyceride lipaseprovided by RGD
    Primary source
    RGD:71039
    See related
    EnsemblRapid:ENSRNOG00000014508 AllianceGenome:RGD:71039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MAGL
    Summary
    Enables monoacylglycerol lipase activity. Involved in monoacylglycerol catabolic process and positive regulation of vasoconstriction. Is active in presynapse. Orthologous to human MGLL (monoglyceride lipase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 964.0), Testes (RPKM 606.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mgll in Genome Data Viewer
    Location:
    4q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122749436..122851440)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121192186..121294187)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120671436..120773458)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 12 Neighboring gene uncharacterized LOC134486810 Neighboring gene transfer RNA valine (anticodon AAC) 19 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124942

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity PubMed 
    enables hydrolase activity PubMed 
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity PubMed 
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process  
    involved_in acylglycerol catabolic process  
    involved_in acylglycerol metabolic process  
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process  
    involved_in fatty acid biosynthetic process  
    acts_upstream_of_or_within long-term synaptic depression  
    involved_in monoacylglycerol catabolic process PubMed 
    involved_in monoacylglycerol catabolic process  
    involved_in positive regulation of vasoconstriction PubMed 
    acts_upstream_of_or_within regulation of axon extension  
    involved_in regulation of endocannabinoid signaling pathway  
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid  
    involved_in regulation of sensory perception of pain  
    involved_in regulation of sensory perception of pain  
    involved_in regulation of signal transduction  
    involved_in regulation of signal transduction  
    involved_in triglyceride catabolic process  
    Component Evidence Code Pubs
    located_in axon  
    is_active_in cerebellar climbing fiber to Purkinje cell synapse  
    located_in cytosol  
    located_in cytosol  
    located_in lipid droplet  
    is_active_in membrane  
    located_in membrane  
    located_in membrane  
    is_active_in parallel fiber to Purkinje cell synapse  
    is_active_in presynapse PubMed 
    is_active_in presynapse  
    located_in synapse  
    located_in varicosity  

    General protein information

    Preferred Names
    monoglyceride lipase
    Names
    MGL
    monoacylglycerol lipase
    NP_001385526.1
    NP_612511.1
    XP_063141749.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398597.1NP_001385526.1  monoglyceride lipase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZPF3, A6IB48
      Related
      ENSRNOP00000030271.6, ENSRNOT00000029125.8
      Conserved Domains (1) summary
      cl21494
      Location:38312
      Abhydrolase; alpha/beta hydrolases
    2. NM_138502.3NP_612511.1  monoglyceride lipase isoform 2

      See identical proteins and their annotated locations for NP_612511.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q32PZ2, Q8R431
      UniProtKB/TrEMBL
      A0A8I5ZPF3, A6IB49
      Conserved Domains (2) summary
      pfam12146
      Location:41275
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:22296
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      122749436..122851440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285679.1XP_063141749.1  monoglyceride lipase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPF3
      Related
      ENSRNOP00000080270.2, ENSRNOT00000110964.2
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