Pnldc1 PARN like ribonuclease domain containing exonuclease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnldc1provided by RGD
Official Full Name: PARN like ribonuclease domain containing exonuclease 1provided by RGD
Primary source: RGD:1308678
See related: EnsemblRapid:ENSRNOG00000023140 AllianceGenome:RGD:1308678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity and poly(A)-specific ribonuclease activity. Predicted to be involved in negative regulation of gene expression and spermatogenesis. Predicted to act upstream of or within blastocyst formation. Predicted to be active in endoplasmic reticulum and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 57. Orthologous to human PNLDC1 (PARN like ribonuclease domain containing exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 19.9), Thymus (RPKM 16.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50390884..50409457)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47843224..47861675)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48038830..48058400)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in priRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(A)-specific ribonuclease PNLDC1

Names: PARN like, ribonuclease domain containing 1; poly(A)-specific ribonuclease (PARN)-like domain containing 1; poly(A)-specific ribonuclease PARN-like domain-containing protein 1

NP_001382522.1

EC 3.1.13.4

XP_063122219.1

EC 3.1.13.4

XP_063122222.1

EC 3.1.13.4

XP_063122225.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.