Kif7 kinesin family member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif7provided by RGD
Official Full Name: kinesin family member 7provided by RGD
Primary source: RGD:1310310
See related: EnsemblRapid:ENSRNOG00000026857 AllianceGenome:RGD:1310310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in microtubule-based movement; negative regulation of smoothened signaling pathway; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Predicted to be located in ciliary basal body and ciliary tip. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 42.6), Lung (RPKM 31.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (143041206..143067873, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (133639487..133658539, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (141434183..141452592, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I.
Title: Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I.
Decreased Kif7 expression during diaphragmatic development may result in diaphragmatic defects in the nitrofen-induced congenital diaphragmatic hernia model.
Title: Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary tip	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432145.1 → NP_001419074.1 kinesin-like protein KIF7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4A9P0
NM_001432146.1 → NP_001419075.1 kinesin-like protein KIF7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432147.1 → NP_001419076.1 kinesin-like protein KIF7 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

143041206..143067873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229415.5 → XP_006229477.1 kinesin-like protein KIF7 isoform X3

Conserved Domains (4) summary

smart00129
Location:15 → 356

KISc; Kinesin motor, catalytic domain. ATPase

COG1340
Location:700 → 1039

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

cl02164
Location:847 → 1027

Utp11; Utp11 protein
XM_063278924.1 → XP_063134994.1 kinesin-like protein KIF7 isoform X4
XM_006229414.5 → XP_006229476.1 kinesin-like protein KIF7 isoform X2

Related

ENSRNOP00000109737.1, ENSRNOT00000137982.1

Conserved Domains (4) summary

smart00129
Location:15 → 356

KISc; Kinesin motor, catalytic domain. ATPase

COG1340
Location:700 → 1039

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

cl02164
Location:847 → 1027

Utp11; Utp11 protein
XM_218828.11 → XP_218828.5 kinesin-like protein KIF7 isoform X1

Related

ENSRNOP00000100424.1, ENSRNOT00000166617.1

Conserved Domains (4) summary

smart00129
Location:15 → 356

KISc; Kinesin motor, catalytic domain. ATPase

COG1340
Location:701 → 1040

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01372
Location:15 → 350

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

cl02164
Location:848 → 1028

Utp11; Utp11 protein