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    Rab43 RAB43, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab43provided by RGD
    Official Full Name
    RAB43, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1565300
    See related
    EnsemblRapid:ENSRNOG00000037768 AllianceGenome:RGD:1565300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in several processes, including autophagosome assembly; phagosome maturation; and retrograde transport, plasma membrane to Golgi. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in Golgi apparatus and phagocytic vesicle. Predicted to be active in endomembrane system. Orthologous to human RAB43 (RAB43, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 239.4), Liver (RPKM 153.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab43 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121806992..121826694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120249650..120269174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119695012..119714490, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910604 Neighboring gene EF-hand and coiled-coil domain containing 1 Neighboring gene glycoprotein IX (platelet) Neighboring gene ISY1 splicing factor homolog Neighboring gene CCHC-type zinc finger, nucleic acid binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70. Fujita A, et al. PLoS One, 2013. PMID 24223996, Free PMC Article
    2. Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. Zenner HL, et al. J Virol, 2011 Aug. PMID 21680502, Free PMC Article
    3. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. Haas AK, et al. J Cell Sci, 2007 Sep 1. PMID 17684057
    4. Rab18 and a Rab18 GEF complex are required for normal ER structure. Gerondopoulos A, et al. J Cell Biol, 2014 Jun 9. PMID 24891604, Free PMC Article
    5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Seto S, et al. Traffic, 2011 Apr. PMID 21255211

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth
      Title: GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, plasma membrane to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, plasma membrane to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in virion assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-43
    Names
    Ras-related protein RAB43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024331.2 → NP_001019502.1  ras-related protein Rab-43

      See identical proteins and their annotated locations for NP_001019502.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q53B90
      Related
      ENSRNOP00000013299.4, ENSRNOT00000013299.6
      Conserved Domains (1) summary
      cd01864
      Location:14 → 178
      Rab19; Rab GTPase family 19 (Rab19)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121806992..121826694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286535.1 → XP_063142605.1  ras-related protein Rab-43 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWQ6

    2. XM_063286536.1 → XP_063142606.1  ras-related protein Rab-43 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53B90.1 GenPept UniProtKB/Swiss-Prot:Q53B90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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