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    Twf2 twinfilin actin-binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684352, updated on 9-Dec-2024

    Summary

    Official Symbol
    Twf2provided by RGD
    Official Full Name
    twinfilin actin-binding protein 2provided by RGD
    Primary source
    RGD:1591460
    See related
    EnsemblRapid:ENSRNOG00000048915 AllianceGenome:RGD:1591460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; anion binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including actin filament depolymerization; negative regulation of actin filament polymerization; and positive regulation of cell projection organization. Predicted to be located in several cellular components, including growth cone; lamellipodium; and stereocilium. Predicted to be active in actin filament and myofibril. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 439.9), Muscle (RPKM 246.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Twf2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115723980..115737025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106845253..106858298)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114897011..114909531)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene microRNA let-7g Neighboring gene WD repeat domain 82 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1M Neighboring gene toll-like receptor 9 Neighboring gene 5'-aminolevulinate synthase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables actin monomer binding  
    enables actin monomer binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables protein kinase C binding  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization  
    involved_in barbed-end actin filament capping  
    involved_in barbed-end actin filament capping  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to retinoic acid  
    involved_in negative regulation of actin filament polymerization  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of lamellipodium assembly  
    involved_in sequestering of actin monomers  
    involved_in sequestering of actin monomers  
    Component Evidence Code Pubs
    is_active_in actin filament  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in filopodium  
    located_in growth cone  
    located_in lamellipodium  
    is_active_in myofibril  
    located_in myofibril  
    located_in perinuclear region of cytoplasm  
    located_in stereocilium  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135238.1NP_001128710.1  twinfilin-2

      See identical proteins and their annotated locations for NP_001128710.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A0A8I6A2H9, B0BMY7, M0RAP2
      Related
      ENSRNOP00000066595.2, ENSRNOT00000074683.3
      Conserved Domains (2) summary
      cd11284
      Location:176311
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115723980..115737025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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