U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Krt12 keratin 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360625, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Krt12provided by RGD
    Official Full Name
    keratin 12provided by RGD
    Primary source
    RGD:1304805
    See related
    EnsemblRapid:ENSRNOG00000011986 AllianceGenome:RGD:1304805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ka12; Krt1-12
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in several processes, including cornea development in camera-type eye; epithelial cell differentiation; and intermediate filament organization. Predicted to act upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 5.0), Muscle (RPKM 2.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Krt12 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84866965..84874265, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (84370803..84378103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (87328547..87336710, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352132 Neighboring gene keratin 28 Neighboring gene uncharacterized LOC134480872 Neighboring gene keratin 10 Neighboring gene keratin 20 Neighboring gene keratin 23

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Keratin 12-deficient mice have fragile corneal epithelia. Kao WW, et al. Invest Ophthalmol Vis Sci, 1996 Dec. PMID 8977471
    2. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. Irvine AD, et al. Nat Genet, 1997 Jun. PMID 9171831
    3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cornea development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cornea development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cornea development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cornea development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epithelium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in morphogenesis of an epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    keratin, type I cytoskeletal 12
    Names
    CK-12
    K12
    cytokeratin-12
    keratin 12 (Meesmann corneal dystrophy)
    keratin 12, type I
    keratin K12
    keratin complex 1, acidic, gene 12
    type I keratin KA12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395659.1 → NP_001382588.1  keratin, type I cytoskeletal 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6IFW5
      UniProtKB/TrEMBL
      A0A0G2K4H9
      Related
      ENSRNOP00000073050.1, ENSRNOT00000079297.3
      Conserved Domains (1) summary
      pfam00038
      Location:114 → 424
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84866965..84874265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269430.1 → XP_063125500.1  keratin, type I cytoskeletal 12 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008761.1: Suppressed sequence

      Description
      NM_001008761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IFW5.1 GenPept UniProtKB/Swiss-Prot:Q6IFW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools