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    Emp2 epithelial membrane protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360468, updated on 4-Jan-2025

    Summary

    Symbol
    Emp2provided by RGD
    Full Name
    epithelial membrane protein 2provided by RGD
    Primary source
    RGD:1359629
    See related
    EnsemblRapid:ENSRNOG00000002664 AllianceGenome:RGD:1359629
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EMP-2
    Summary
    Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including bleb assembly; early endosome to late endosome transport; and embryonic process involved in female pregnancy. Predicted to act upstream of or within positive regulation of cell-matrix adhesion. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 1035.7), Heart (RPKM 126.5) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Emp2 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5866869..5901533)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (5360073..5394734)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (5433248..5467840)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553451 Neighboring gene tektin 5 Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene uncharacterized LOC134480748 Neighboring gene ribosomal protein L39 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93695

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding  
    enables kinase binding  
    enables protein kinase binding  
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in T cell mediated cytotoxicity  
    involved_in T cell mediated cytotoxicity  
    involved_in actin filament organization  
    involved_in actin filament organization  
    involved_in actin-mediated cell contraction  
    involved_in actin-mediated cell contraction  
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in bleb assembly  
    involved_in bleb assembly  
    involved_in blood vessel endothelial cell migration  
    involved_in blood vessel endothelial cell migration  
    NOT involved_in caveola assembly  
    NOT involved_in caveola assembly  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in early endosome to late endosome transport  
    involved_in early endosome to late endosome transport  
    involved_in embryo implantation  
    involved_in embryo implantation  
    involved_in embryonic process involved in female pregnancy  
    involved_in embryonic process involved in female pregnancy  
    involved_in heart formation  
    involved_in heart formation  
    involved_in membrane raft assembly  
    involved_in membrane raft assembly  
    involved_in natural killer cell proliferation  
    involved_in natural killer cell proliferation  
    involved_in neutrophil migration  
    involved_in neutrophil migration  
    involved_in plasma membrane raft assembly  
    involved_in plasma membrane raft assembly  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of cardiac epithelial to mesenchymal transition  
    involved_in positive regulation of cardiac epithelial to mesenchymal transition  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion  
    involved_in positive regulation of integrin-mediated signaling pathway  
    acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway  
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in regulation of angiogenesis  
    involved_in regulation of angiogenesis  
    involved_in regulation of cell-matrix adhesion  
    involved_in regulation of cell-matrix adhesion  
    involved_in regulation of endothelial cell migration  
    involved_in regulation of endothelial cell migration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of kinase activity  
    involved_in regulation of kinase activity  
    involved_in regulation of vasculogenesis  
    involved_in regulation of vasculogenesis  
    Items 1 - 25 of 60
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in apical part of cell  
    located_in apical part of cell  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    NOT located_in caveola  
    NOT located_in caveola  
    located_in cell surface  
    located_in cell surface  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in membrane raft  
    located_in membrane raft  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    epithelial membrane protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007721.1NP_001007722.1  epithelial membrane protein 2

      See identical proteins and their annotated locations for NP_001007722.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081865
      UniProtKB/Swiss-Prot
      Q66HH2
      Related
      ENSRNOP00000003615.4, ENSRNOT00000003615.6
      Conserved Domains (1) summary
      pfam00822
      Location:1165
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      5866869..5901533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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