Cdc23 cell division cycle 23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc23provided by RGD
Official Full Name: cell division cycle 23provided by RGD
Primary source: RGD:1304819
See related: EnsemblRapid:ENSRNOG00000024241 AllianceGenome:RGD:1304819
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 179.6), Spleen (RPKM 133.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26511019..26534872, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (26236891..26260611, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27430924..27452569, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D18Rat130 (e-PCR), detects polymorphism
- UniSTS:226924

RH136974 (e-PCR)
- UniSTS:219063

RH132745 (e-PCR)
- UniSTS:216028

AA859935 (e-PCR)
- UniSTS:243956

RH127370 (e-PCR)
- UniSTS:210680

RH140853 (e-PCR)
- UniSTS:210680

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein branched polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell division cycle protein 23 homolog

Names: CDC23 (cell division cycle 23, yeast, homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100659.1 → NP_001094129.1 cell division cycle protein 23 homolog

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

F1LRQ6

Related

ENSRNOP00000089789.2, ENSRNOT00000101231.2

Conserved Domains (3) summary

COG0457
Location:216 → 451

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:367 → 393

TPR; TPR repeat [structural motif]

pfam04049
Location:45 → 148

ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

26511019..26534872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277222.1 → XP_063133292.1 cell division cycle protein 23 homolog isoform X1

UniProtKB/TrEMBL

F1LRQ6
XM_008772028.4 → XP_008770250.1 cell division cycle protein 23 homolog isoform X2

See identical proteins and their annotated locations for XP_008770250.1

UniProtKB/TrEMBL

A0A8I5ZTG0, A6J2V5, F1LRQ6

Related

ENSRNOP00000082129.1, ENSRNOT00000110937.2

Conserved Domains (5) summary

COG0457
Location:212 → 399

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:367 → 393

TPR; TPR repeat [structural motif]

pfam00515
Location:331 → 364

TPR_1; Tetratricopeptide repeat

pfam04049
Location:28 → 154

ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

pfam13414
Location:367 → 430

TPR_11; TPR repeat