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    Zfp667 zinc finger protein 667 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp667provided by RGD
    Official Full Name
    zinc finger protein 667provided by RGD
    Primary source
    RGD:1359114
    See related
    EnsemblRapid:ENSRNOG00000033906 AllianceGenome:RGD:1359114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mip1; Znf667
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF667 (zinc finger protein 667). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 46.1), Muscle (RPKM 39.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp667 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (76634897..76655133, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (67601803..67622041, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (71270101..71290337, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482884 Neighboring gene zinc finger protein 829 like, pseudogene 1 Neighboring gene zinc finger protein 583 Neighboring gene uncharacterized LOC134482883 Neighboring gene zinc finger and SCAN domain containing 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein. Qu S, et al. Free Radic Biol Med, 2010 Aug 15. PMID 20488243
    2. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene. Wang G, et al. Braz J Med Biol Res, 2010 Jan. PMID 19649394
    3. Identification and characterization of the minimal promoter of Mipu1: the role of GC boxes in the regulation of basal transcription. Lv B, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Apr. PMID 19352546
    4. Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway. Wang G, et al. Mol Cell Biochem, 2009 Feb. PMID 19015817
    5. ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells. Jiang L, et al. PLoS One, 2014. PMID 25397408, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF667 that confers cytoprotection is a novel regulator of the rat Bax gene.
      Title: ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells.
    2. Mip1 over-expression inhibited H2O2-induced apoptosis and upregulation of Fas induced by H2O2 in H9c2 myogenic cells.
      Title: Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas.
    3. Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway.
      Title: Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection.
    4. The H(2)O(2)-induced up-regulation of Mipu1 in H9c2 cardiomyocytes was mediated by cAMP/PKA-dependent CREB activation.
      Title: Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein.
    5. Results found that Mipu1 was highly expressed in the heart and brain of rats and was localized in the nucleus of H9c2 myogenic cells and lay the foundation for further study of the biological functions of Mipu1.
      Title: Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene.
    6. These results suggested that Mipu1 protein might act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions
      Title: Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway.
    7. Results indicate that the GC boxes are essential for the activity of the Mipu1 minimal promoter activity
      Title: Identification and characterization of the minimal promoter of Mipu1: the role of GC boxes in the regulation of basal transcription.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 667
    Names
    myocardial ischemic preconditioning up-regulated protein 1
    myocardial ischemic preconditioning upregulated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008557.1 → NP_001008557.1  zinc finger protein 667

      See identical proteins and their annotated locations for NP_001008557.1

      Status: VALIDATED

      Source sequence(s)
      AY221750
      UniProtKB/Swiss-Prot
      Q5MYW4
      Related
      ENSRNOP00000061115.4, ENSRNOT00000063956.5
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:456 → 480
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      76634897..76655133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228189.4 → XP_006228251.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_006228251.1

      UniProtKB/Swiss-Prot
      Q5MYW4
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:456 → 480
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MYW4.1 GenPept UniProtKB/Swiss-Prot:Q5MYW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
    Miscellaneous