Vip vasoactive intestinal peptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vipprovided by RGD
Official Full Name: vasoactive intestinal peptideprovided by RGD
Primary source: RGD:621647
See related: EnsemblRapid:ENSRNOG00000018808 AllianceGenome:RGD:621647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: vip/phi27
Summary: Enables hormone activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; and positive regulation of penile erection. Located in neuronal cell body. Used to study several diseases, including Parkinsonism; brain ischemia; periodontitis; pulmonary hypertension; and uveitis. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 54.8), Adrenal (RPKM 4.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (44470232..44478561)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (42064878..42073219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (42169307..42177582)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
Title: Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
Title: Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
Title: Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
Title: Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
VIP could activate neonatal rat primordial follicle through the ERK-mTOR signalling pathway, suggesting a strategy for in vitro primordial follicle recruitment.
Title: VIP activates primordial follicles of rat through ERK-mTOR pathway in tissue culture.
The expressions of CGRP and VIP were significantly down-regulated in the erectile dysfunction rat model
Title: [Expressions of calcitonin gene-related peptide and vasoactive intestinal peptide in the penile tissue of the ED rat model and their action mechanisms].
Study shows that sciatic nerve chronic constriction injury that triggers neuropathic pain and persistent disability results in abnormally increased vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide expression in the periaqueductal grey.
Title: PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury.
findings indicate that PACAP and VIP can prevent the deleterious effect of Oxygen/Glucose Deprivation on rat neuronal cells.
Title: The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.
VIP is an important regulator of cardiovascular and digestive system in physiological and pathological conditions
Title: Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats.
Data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes.
Title: Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (63)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 1 vasoactive intestinal polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 vasoactive intestinal polypeptide receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 2 vasoactive intestinal polypeptide receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in epinephrine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of penile erection	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in prolactin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: VIP peptides

Names: vasoactive intestinal polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053991.1 → NP_446443.1 VIP peptides preproprotein

See identical proteins and their annotated locations for NP_446443.1

Status: VALIDATED

Source sequence(s)

BC158798, CB583853

UniProtKB/Swiss-Prot

P01283, Q9QUN1

UniProtKB/TrEMBL

A0A090AX27, A0A090BZQ0, A0A1B0GWR8, A6KIN8

Related

ENSRNOP00000025477.6, ENSRNOT00000025477.8

Conserved Domains (1) summary

pfam00123
Location:81 → 108

Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

44470232..44478561

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078200.2 → XP_038934128.1 VIP peptides isoform X3

UniProtKB/TrEMBL

A0A1B0GWR8

Conserved Domains (1) summary

pfam00123
Location:81 → 108

Hormone_2; Peptide hormone
XM_017588692.3 → XP_017444181.1 VIP peptides isoform X1

UniProtKB/TrEMBL

A0A1B0GWR8, B0BNF3

Conserved Domains (1) summary

pfam00123
Location:81 → 107

Hormone_2; Peptide hormone
XM_017588691.3 → XP_017444180.1 VIP peptides isoform X2

UniProtKB/TrEMBL

A0A1B0GWR8

Conserved Domains (1) summary

pfam00123
Location:81 → 107

Hormone_2; Peptide hormone