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    Uba6 ubiquitin-like modifier activating enzyme 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305268, updated on 27-Dec-2024

    Summary

    Official Symbol
    Uba6provided by RGD
    Official Full Name
    ubiquitin-like modifier activating enzyme 6provided by RGD
    Primary source
    RGD:1308324
    See related
    EnsemblRapid:ENSRNOG00000021931 AllianceGenome:RGD:1308324
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ube1l2; RGD1308324
    Summary
    Predicted to enable FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 194.8), Adrenal (RPKM 157.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Uba6 in Genome Data Viewer
    Location:
    14p21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (22238832..22302650)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (21884039..21947857)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (23507628..23571446)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11C Neighboring gene uncharacterized LOC103692776 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene signal transducing adaptor family member 1 Neighboring gene centromere protein C Neighboring gene actin, alpha 1, skeletal muscle, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAT10 activating enzyme activity  
    enables FAT10 activating enzyme activity  
    enables ubiquitin activating enzyme activity  
    enables ubiquitin activating enzyme activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme 6
    Names
    ubiquitin-activating enzyme E1-like 2
    NP_001100683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107213.1NP_001100683.1  ubiquitin-like modifier-activating enzyme 6

      See identical proteins and their annotated locations for NP_001100683.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473981
      UniProtKB/TrEMBL
      A0A8I6AS92, A6JCR8, D4A8H3
      Related
      ENSRNOP00000030667.4, ENSRNOT00000037509.7
      Conserved Domains (4) summary
      cd01490
      Location:4621005
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:43428
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:381046
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:298358
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      22238832..22302650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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