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    P2ry12 purinergic receptor P2Y12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64803, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2ry12provided by RGD
    Official Full Name
    purinergic receptor P2Y12provided by RGD
    Primary source
    RGD:621681
    See related
    EnsemblRapid:ENSRNOG00000013902 AllianceGenome:RGD:621681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2y12
    Summary
    Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; monoatomic cation transmembrane transport; and positive regulation of cellular component biogenesis. Located in basal plasma membrane; caveola; and external side of plasma membrane. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See P2ry12 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145631487..145673194, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143481468..143523340, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149440807..149482592, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene arylacetamide deacetylase-like 2 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 43
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway PubMed 
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium-mediated signaling PubMed 
    involved_in cell projection organization PubMed 
    involved_in cellular response to ATP PubMed 
    involved_in cellular response to ATP  
    involved_in cellular response to ATP  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    involved_in cerebral cortex radial glia-guided migration PubMed 
    acts_upstream_of establishment of localization in cell  
    involved_in glial cell migration PubMed 
    involved_in lamellipodium assembly PubMed 
    acts_upstream_of monoatomic ion transport  
    involved_in negative regulation of cell differentiation PubMed 
    involved_in negative regulation of norepinephrine secretion PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within platelet activation  
    involved_in platelet aggregation  
    involved_in platelet aggregation  
    involved_in positive regulation of cell adhesion mediated by integrin PubMed 
    involved_in positive regulation of chemotaxis PubMed 
    involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction PubMed 
    involved_in positive regulation of microglial cell migration PubMed 
    acts_upstream_of_or_within positive regulation of monoatomic ion transport  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of ruffle assembly PubMed 
    involved_in potassium ion transmembrane transport PubMed 
    involved_in regulation of calcium ion transport PubMed 
    involved_in regulation of chemotaxis PubMed 
    involved_in regulation of microglial cell migration  
    involved_in regulation of microglial cell migration  
    involved_in response to axon injury PubMed 
    involved_in substrate-dependent cell migration, cell extension  
    involved_in substrate-dependent cell migration, cell extension  
    involved_in visual system development  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    located_in basal plasma membrane PubMed 
    located_in caveola PubMed 
    located_in cell body membrane  
    located_in cell projection membrane  
    located_in external side of plasma membrane PubMed 
    located_in membrane  
    located_in membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    P2Y purinoceptor 12
    Names
    P2Y12 platelet ADP receptor
    purinergic receptor P2Y, G-protein coupled, 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022800.1NP_073637.1  P2Y purinoceptor 12

      See identical proteins and their annotated locations for NP_073637.1

      Status: PROVISIONAL

      Source sequence(s)
      AF313450
      UniProtKB/Swiss-Prot
      Q9EPX4
      UniProtKB/TrEMBL
      A6JVK4
      Related
      ENSRNOP00000018600.2, ENSRNOT00000018600.6
      Conserved Domains (1) summary
      pfam00001
      Location:67304
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      145631487..145673194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232407.5XP_006232469.1  P2Y purinoceptor 12 isoform X1

      See identical proteins and their annotated locations for XP_006232469.1

      UniProtKB/Swiss-Prot
      Q9EPX4
      UniProtKB/TrEMBL
      A6JVK4
      Related
      ENSRNOP00000089320.2, ENSRNOT00000097839.2
      Conserved Domains (1) summary
      pfam00001
      Location:67304
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_063282498.1XP_063138568.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9EPX4
      UniProtKB/TrEMBL
      A6JVK4
    3. XM_063282499.1XP_063138569.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9EPX4
      UniProtKB/TrEMBL
      A6JVK4
    4. XM_006232408.5XP_006232470.1  P2Y purinoceptor 12 isoform X1

      See identical proteins and their annotated locations for XP_006232470.1

      UniProtKB/Swiss-Prot
      Q9EPX4
      UniProtKB/TrEMBL
      A6JVK4
      Conserved Domains (1) summary
      pfam00001
      Location:67304
      7tm_1; 7 transmembrane receptor (rhodopsin family)
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