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    Kif21a kinesin family member 21A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif21aprovided by RGD
    Official Full Name
    kinesin family member 21Aprovided by RGD
    Primary source
    RGD:1305126
    See related
    EnsemblRapid:ENSRNOG00000014844 AllianceGenome:RGD:1305126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; ankyrin repeat binding activity; and plus-end-directed microtubule motor activity. Involved in anterograde axonal transport. Is active in presynapse. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 220.6), Kidney (RPKM 137.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif21a in Genome Data Viewer
    Location:
    7q35
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (123942079..124058594, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (122062523..122179051, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (132069962..132200947, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene polypyrimidine tract binding protein 1, pseudogene 5 Neighboring gene aph-1 homolog A, gamma secretase subunit, pseudogene 1 Neighboring gene uncharacterized LOC134479768 Neighboring gene uncharacterized LOC108351528 Neighboring gene uncharacterized LOC120093710 Neighboring gene ATP binding cassette subfamily D member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2. Lee KH, et al. J Neurosci, 2012 Mar 21. PMID 22442075, Free PMC Article
    2. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
    3. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Choe EA, et al. J Neurosci, 2007 Aug 29. PMID 17728463, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cortical microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF21A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371538.1 → NP_001358467.1  kinesin-like protein KIF21A

      Status: VALIDATED

      Source sequence(s)
      FQ096185, JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZCG2, D3ZYN2
      Related
      ENSRNOP00000031911.6, ENSRNOT00000038946.9
      Conserved Domains (5) summary
      pfam05483
      Location:642 → 1040
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG1196
      Location:381 → 779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00200
      Location:1337 → 1650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1388 → 1447
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      123942079..124058594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263363.1 → XP_063119433.1  kinesin-like protein KIF21A isoform X22

      UniProtKB/TrEMBL
      D3ZJJ7

    2. XM_063263362.1 → XP_063119432.1  kinesin-like protein KIF21A isoform X21

      UniProtKB/TrEMBL
      D3ZJJ7

    3. XM_063263354.1 → XP_063119424.1  kinesin-like protein KIF21A isoform X11

      UniProtKB/TrEMBL
      A0A8I6AEJ5, A0A8I6AMC6
      Related
      ENSRNOP00000092894.2, ENSRNOT00000110235.2

    4. XM_063263359.1 → XP_063119429.1  kinesin-like protein KIF21A isoform X18

      UniProtKB/TrEMBL
      D3ZJJ7, D4A1V5
      Related
      ENSRNOP00000040915.5, ENSRNOT00000046744.7

    5. XM_063263349.1 → XP_063119419.1  kinesin-like protein KIF21A isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1X3
      Related
      ENSRNOP00000085651.2, ENSRNOT00000119582.2

    6. XM_039078881.2 → XP_038934809.1  kinesin-like protein KIF21A isoform X1

      UniProtKB/TrEMBL
      D3ZYN2
      Conserved Domains (6) summary
      COG0419
      Location:344 → 1026
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00200
      Location:1342 → 1655
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      TIGR02168
      Location:645 → 848
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1393 → 1452
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:938 → 1019
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    7. XM_063263352.1 → XP_063119422.1  kinesin-like protein KIF21A isoform X7

      UniProtKB/TrEMBL
      D3ZYN2
      Related
      ENSRNOP00000052600.4, ENSRNOT00000055742.6

    8. XM_063263351.1 → XP_063119421.1  kinesin-like protein KIF21A isoform X6

      UniProtKB/TrEMBL
      D3ZYN2

    9. XM_063263348.1 → XP_063119418.1  kinesin-like protein KIF21A isoform X3

      UniProtKB/TrEMBL
      D3ZYN2
      Related
      ENSRNOP00000044677.4, ENSRNOT00000044092.7

    10. XM_063263353.1 → XP_063119423.1  kinesin-like protein KIF21A isoform X10

      UniProtKB/TrEMBL
      D3ZYN2

    11. XM_039078882.2 → XP_038934810.1  kinesin-like protein KIF21A isoform X2

      UniProtKB/TrEMBL
      D3ZYN2
      Conserved Domains (6) summary
      COG0419
      Location:348 → 1030
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00200
      Location:1341 → 1654
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      TIGR02168
      Location:649 → 852
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1392 → 1451
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:942 → 1023
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    12. XM_063263350.1 → XP_063119420.1  kinesin-like protein KIF21A isoform X5

      UniProtKB/TrEMBL
      D3ZYN2

    13. XM_063263358.1 → XP_063119428.1  kinesin-like protein KIF21A isoform X16

      UniProtKB/TrEMBL
      D3ZYN2

    14. XM_039078888.2 → XP_038934816.1  kinesin-like protein KIF21A isoform X9

      UniProtKB/TrEMBL
      A0A8I6AMC6
      Conserved Domains (6) summary
      COG1196
      Location:385 → 770
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:633 → 1016
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00200
      Location:1308 → 1621
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1359 → 1418
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    15. XM_063263365.1 → XP_063119435.1  kinesin-like protein KIF21A isoform X26

      UniProtKB/TrEMBL
      D3ZJJ7

    16. XM_063263357.1 → XP_063119427.1  kinesin-like protein KIF21A isoform X15

      UniProtKB/TrEMBL
      D3ZYN2

    17. XM_063263361.1 → XP_063119431.1  kinesin-like protein KIF21A isoform X20

      UniProtKB/TrEMBL
      D3ZJJ7

    18. XM_063263355.1 → XP_063119425.1  kinesin-like protein KIF21A isoform X12

      UniProtKB/TrEMBL
      D3ZYN2

    19. XM_039078898.2 → XP_038934826.1  kinesin-like protein KIF21A isoform X25

      UniProtKB/TrEMBL
      D3ZJJ7
      Conserved Domains (6) summary
      COG1196
      Location:385 → 770
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:633 → 1016
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00200
      Location:1242 → 1555
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1293 → 1352
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    20. XM_039078887.2 → XP_038934815.1  kinesin-like protein KIF21A isoform X8

      UniProtKB/TrEMBL
      A0A8I6A1X3
      Conserved Domains (6) summary
      COG1196
      Location:385 → 770
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:633 → 1016
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00200
      Location:1315 → 1628
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1366 → 1425
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    21. XM_063263364.1 → XP_063119434.1  kinesin-like protein KIF21A isoform X24

      UniProtKB/TrEMBL
      D3ZJJ7

    22. XM_063263356.1 → XP_063119426.1  kinesin-like protein KIF21A isoform X14

      UniProtKB/TrEMBL
      D3ZYN2

    23. XM_063263366.1 → XP_063119436.1  kinesin-like protein KIF21A isoform X28

      UniProtKB/TrEMBL
      D3ZJJ7

    24. XM_063263360.1 → XP_063119430.1  kinesin-like protein KIF21A isoform X19

      UniProtKB/TrEMBL
      D3ZJJ7

    25. XM_039078896.2 → XP_038934824.1  kinesin-like protein KIF21A isoform X23

      UniProtKB/TrEMBL
      D3ZJJ7
      Conserved Domains (6) summary
      COG1196
      Location:385 → 770
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:633 → 1016
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00200
      Location:1249 → 1562
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1300 → 1359
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    26. XM_039078892.2 → XP_038934820.1  kinesin-like protein KIF21A isoform X13

      UniProtKB/TrEMBL
      D3ZSN6
      Conserved Domains (6) summary
      COG0419
      Location:348 → 1017
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00200
      Location:1285 → 1598
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      TIGR02168
      Location:636 → 839
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1336 → 1395
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    27. XM_039078899.2 → XP_038934827.1  kinesin-like protein KIF21A isoform X27

      UniProtKB/TrEMBL
      D3ZJJ7
      Conserved Domains (6) summary
      COG1196
      Location:385 → 770
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:633 → 1016
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd00200
      Location:1236 → 1549
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1287 → 1346
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    28. XM_039078893.2 → XP_038934821.1  kinesin-like protein KIF21A isoform X17

      UniProtKB/TrEMBL
      D3ZJJ7
      Conserved Domains (6) summary
      COG0419
      Location:348 → 1017
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00200
      Location:1272 → 1585
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      TIGR02168
      Location:636 → 839
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01372
      Location:18 → 376
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1323 → 1382
      7WD40; WD40 repeat [structural motif]
      cd22263
      Location:929 → 1010
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106790.1: Suppressed sequence

      Description
      NM_001106790.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: KIF21A (GeneID:55605).
    Nucleotide Protein Strain
    Heading Accession and Version

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