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    Stab2 stabilin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282580, updated on 9-Dec-2024

    Summary

    Symbol
    Stab2provided by RGD
    Full Name
    stabilin 2provided by RGD
    Primary source
    RGD:628822
    See related
    EnsemblRapid:ENSRNOG00000038948 AllianceGenome:RGD:628822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hare; FEEL-2; RGD1560941
    Summary
    Enables hyaluronic acid binding activity. Involved in endocytosis. Located in external side of plasma membrane. Orthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 366.0) and Liver (RPKM 180.2) See more
    Orthologs
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    Genomic context

    See Stab2 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    72
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (23136938..23342633, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (21249426..21433051, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (27369853..27552078, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene uncharacterized LOC120093791 Neighboring gene ADNP homeobox 2 like 1 Neighboring gene ribosomal protein L7a, pseudogene 27 Neighboring gene uncharacterized LOC134479852 Neighboring gene similar to human chromosome 12 open reading frame 42 Neighboring gene uncharacterized LOC108351426

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables cargo receptor activity  
    enables hyaluronic acid binding PubMed 
    enables hyaluronic acid binding  
    enables low-density lipoprotein particle binding  
    enables low-density lipoprotein particle binding  
    enables low-density lipoprotein particle receptor activity  
    enables low-density lipoprotein particle receptor activity  
    enables scavenger receptor activity  
    enables scavenger receptor activity  
    Process Evidence Code Pubs
    involved_in cell adhesion  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to bacterium  
    involved_in endocytosis PubMed 
    involved_in hyaluronan catabolic process  
    involved_in hyaluronan catabolic process  
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in external side of plasma membrane PubMed 
    located_in membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    stabilin-2
    Names
    fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
    hyaluronan receptor for endocytosis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246357.2NP_001233286.2  stabilin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      E0X583
      Related
      ENSRNOP00000091563.2, ENSRNOT00000099162.2
      Conserved Domains (3) summary
      smart00554
      Location:17641870
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      cl02612
      Location:21852277
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
      cl02663
      Location:16071717
      Fasciclin; Fasciclin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      23136938..23342633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263071.1XP_063119141.1  stabilin-2 isoform X2

      UniProtKB/TrEMBL
      F1LZZ6
    2. XM_063263072.1XP_063119142.1  stabilin-2 isoform X4

      UniProtKB/TrEMBL
      F1LZZ6
    3. XM_039078516.2XP_038934444.1  stabilin-2 isoform X3

      UniProtKB/TrEMBL
      F1LZZ6
      Conserved Domains (5) summary
      smart00554
      Location:23602449
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:17541885
      Fasciclin; Fasciclin domain
      pfam12947
      Location:21312168
      EGF_3; EGF domain
      cl02612
      Location:22022294
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
      cl21504
      Location:254283
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. XM_039078515.2XP_038934443.1  stabilin-2 isoform X1

      UniProtKB/TrEMBL
      F1LZZ6
      Related
      ENSRNOP00000056294.5, ENSRNOT00000059538.5
      Conserved Domains (5) summary
      smart00554
      Location:23602449
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:17541885
      Fasciclin; Fasciclin domain
      pfam12947
      Location:21312168
      EGF_3; EGF domain
      cl02612
      Location:22022294
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
      cl21504
      Location:254283
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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