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    Stat5b signal transducer and activator of transcription 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25126, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat5bprovided by RGD
    Official Full Name
    signal transducer and activator of transcription 5Bprovided by RGD
    Primary source
    RGD:3774
    See related
    EnsemblRapid:ENSRNOG00000019075 AllianceGenome:RGD:3774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stat5b in Genome Data Viewer
    Location:
    10q31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86205148..86276178, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85704841..85775856, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88686207..88712313, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5A Neighboring gene signal transducer and activator of transcription 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables chromatin binding PubMed 
    enables double-stranded DNA binding PubMed 
    enables identical protein binding  
    enables nuclear glucocorticoid receptor binding  
    enables nuclear glucocorticoid receptor binding  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein dimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables sequence-specific DNA binding PubMed 
    Items 1 - 25 of 133
    Process Evidence Code Pubs
    involved_in B cell differentiation  
    acts_upstream_of B cell differentiation  
    involved_in Peyer's patch development  
    acts_upstream_of_or_within Peyer's patch development  
    involved_in T cell differentiation in thymus  
    acts_upstream_of_or_within T cell differentiation in thymus  
    involved_in T cell homeostasis  
    acts_upstream_of_or_within T cell homeostasis  
    involved_in activated T cell proliferation  
    acts_upstream_of activated T cell proliferation  
    involved_in acute-phase response PubMed 
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor signaling pathway  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT  
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to hormone stimulus  
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway  
    involved_in defense response  
    involved_in development of secondary female sexual characteristics  
    acts_upstream_of_or_within development of secondary female sexual characteristics  
    involved_in development of secondary male sexual characteristics  
    acts_upstream_of_or_within development of secondary male sexual characteristics  
    involved_in erythrocyte differentiation  
    acts_upstream_of erythrocyte differentiation  
    involved_in erythropoietin-mediated signaling pathway  
    involved_in erythropoietin-mediated signaling pathway  
    involved_in female pregnancy  
    acts_upstream_of_or_within female pregnancy  
    involved_in gamma-delta T cell differentiation  
    acts_upstream_of gamma-delta T cell differentiation  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in lactation  
    acts_upstream_of_or_within lactation  
    involved_in lipid storage  
    acts_upstream_of_or_within lipid storage  
    involved_in liver development PubMed 
    involved_in luteinization PubMed 
    involved_in luteinization  
    acts_upstream_of_or_within luteinization  
    acts_upstream_of lymphocyte differentiation  
    involved_in mast cell migration  
    acts_upstream_of_or_within mast cell migration  
    involved_in mitotic cell cycle  
    acts_upstream_of mitotic cell cycle  
    involved_in myeloid cell apoptotic process  
    acts_upstream_of myeloid cell apoptotic process  
    involved_in natural killer cell differentiation  
    acts_upstream_of natural killer cell differentiation  
    acts_upstream_of_or_within natural killer cell differentiation  
    involved_in natural killer cell mediated cytotoxicity  
    acts_upstream_of natural killer cell mediated cytotoxicity  
    involved_in natural killer cell proliferation  
    acts_upstream_of natural killer cell proliferation  
    involved_in negative regulation of erythrocyte differentiation  
    acts_upstream_of_or_within negative regulation of erythrocyte differentiation  
    involved_in negative regulation of myeloid cell apoptotic process  
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process  
    involved_in positive regulation of B cell differentiation  
    acts_upstream_of_or_within positive regulation of B cell differentiation  
    involved_in positive regulation of activated T cell proliferation  
    acts_upstream_of_or_within positive regulation of activated T cell proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of fibroblast growth factor production PubMed 
    involved_in positive regulation of gamma-delta T cell differentiation  
    acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of inflammatory response  
    acts_upstream_of_or_within positive regulation of inflammatory response  
    involved_in positive regulation of interleukin-2 production  
    acts_upstream_of_or_within positive regulation of interleukin-2 production  
    acts_upstream_of_or_within positive regulation of lymphocyte differentiation  
    involved_in positive regulation of mitotic cell cycle  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle  
    involved_in positive regulation of multicellular organism growth  
    acts_upstream_of_or_within positive regulation of multicellular organism growth  
    involved_in positive regulation of natural killer cell differentiation  
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation  
    involved_in positive regulation of natural killer cell mediated cytotoxicity  
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity  
    involved_in positive regulation of natural killer cell proliferation  
    acts_upstream_of_or_within positive regulation of natural killer cell proliferation  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in progesterone metabolic process  
    acts_upstream_of_or_within progesterone metabolic process  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell adhesion  
    involved_in regulation of cell population proliferation  
    involved_in regulation of epithelial cell differentiation  
    acts_upstream_of_or_within regulation of epithelial cell differentiation  
    involved_in regulation of multicellular organism growth  
    involved_in regulation of steroid metabolic process  
    acts_upstream_of_or_within regulation of steroid metabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to estradiol  
    involved_in response to estradiol  
    involved_in response to ethanol PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to interleukin-15  
    acts_upstream_of_or_within response to interleukin-15  
    involved_in response to interleukin-2  
    acts_upstream_of_or_within response to interleukin-2  
    involved_in response to interleukin-4  
    acts_upstream_of_or_within response to interleukin-4  
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to peptide hormone  
    involved_in response to peptide hormone PubMed 
    involved_in response to peptide hormone PubMed 
    acts_upstream_of_or_within sex differentiation  
    involved_in signal transduction  
    involved_in taurine metabolic process  
    acts_upstream_of_positive_effect taurine metabolic process  
    involved_in transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 133
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    signal transducer and activator of transcription 5B
    Names
    Signal transducer and activator of transcription 5a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022380.2NP_071775.1  signal transducer and activator of transcription 5B

      See identical proteins and their annotated locations for NP_071775.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P52632
      UniProtKB/TrEMBL
      A6HJ61
      Related
      ENSRNOP00000070284.1, ENSRNOT00000081247.3
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86205148..86276178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085258.1XP_038941186.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/Swiss-Prot
      P52632
      UniProtKB/TrEMBL
      A6HJ61
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    2. XM_039085260.2XP_038941188.1  signal transducer and activator of transcription 5B isoform X3

      UniProtKB/Swiss-Prot
      P52632
      Conserved Domains (4) summary
      cd10420
      Location:539683
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:105296
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:298455
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cl03749
      Location:6290
      STAT_int; STAT protein, protein interaction domain
    3. XM_039085256.2XP_038941184.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      P52632
      UniProtKB/TrEMBL
      A0A0G2JSR4
      Related
      ENSRNOP00000026354.2, ENSRNOT00000026354.5
      Conserved Domains (4) summary
      cd10420
      Location:582726
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:148339
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:341498
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:65133
      STAT_int; STAT protein, protein interaction domain
    4. XM_039085259.2XP_038941187.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/Swiss-Prot
      P52632
      UniProtKB/TrEMBL
      A6HJ61
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    5. XM_039085257.2XP_038941185.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/Swiss-Prot
      P52632
      UniProtKB/TrEMBL
      A6HJ61
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
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