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    Wdr26 WD repeat domain 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr26provided by RGD
    Official Full Name
    WD repeat domain 26provided by RGD
    Primary source
    RGD:1565589
    See related
    EnsemblRapid:ENSRNOG00000003723 AllianceGenome:RGD:1565589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565589
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of GID complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 380.4), Adrenal (RPKM 337.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr26 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (95462017..95503826, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92930282..92972061, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99493117..99532775, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear VCP-like Neighboring gene cornichon family member 4 Neighboring gene glutamic acid-rich protein-like Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene coiled-coil domain containing 121, retrogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WD-40 repeat protein 26 protects against oxidative stress-induced injury in astrocytes via Nrf2/HO-1 pathways. Liu Y, et al. Mol Biol Rep, 2022 Feb. PMID 34981336
    2. WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells. Jiang L, et al. Free Radic Biol Med, 2018 Mar. PMID 29253592
    3. WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation. Feng Y, et al. Acta Biochim Biophys Sin (Shanghai), 2016 Dec. PMID 27797717
    4. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. Zhu Y, et al. J Cell Biochem, 2004 Oct 15. PMID 15378603
    5. WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. Sun Z, et al. J Biol Chem, 2013 Jun 7. PMID 23625927, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WD-40 repeat protein 26 protects against oxidative stress-induced injury in astrocytes via Nrf2/HO-1 pathways.
      Title: WD-40 repeat protein 26 protects against oxidative stress-induced injury in astrocytes via Nrf2/HO-1 pathways.
    2. Our research suggests that the protective effect of the WDR26 isoform, MIP2, on the cardiomyocytes against oxidative stress is partly associated with its interaction with VDAC1 and thus inhibiting its expression
      Title: WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells.
    3. After Parkin is translocated at mitochondria, WDR26 can increase mitochondrial protein ubiquitination in hypoxia of H9c2 cells. WDR26 is a mediator of response to hypoxia, and WDR26 plays an important role in hypoxia-mediated autophagy and mitophagy
      Title: WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109081.2 → NP_001102551.2  WD repeat-containing protein 26 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8L2Q1C0
      Related
      ENSRNOP00000005059.6, ENSRNOT00000005059.7

    2. NM_001401444.1 → NP_001388373.1  WD repeat-containing protein 26 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8L2Q1C0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      95462017..95503826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272548.1 → XP_063128618.1  WD repeat-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q1C0
      Related
      ENSRNOP00000101710.1, ENSRNOT00000134715.1

    RNA

    1. XR_005492275.2 RNA Sequence

    2. XR_005492274.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LTR1.2 GenPept UniProtKB/Swiss-Prot:F1LTR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools