Helt helt bHLH transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Heltprovided by RGD
Official Full Name: helt bHLH transcription factorprovided by RGD
Primary source: RGD:1564073
See related: EnsemblRapid:ENSRNOG00000010785 AllianceGenome:RGD:1564073
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hesl; Helt-ps1; RGD1564073
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; regulation of transcription by RNA polymerase II; and suckling behavior. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human HELT (helt bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (52723828..52725610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (45991227..45993045)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (49185560..49187293)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within GABAergic neuron differentiation in basal ganglia	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within suckling behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

Names: HES/HEY-like transcription factor, pseudogene 1; Hey-like transcription factor

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_008771272.3 → XP_008769494.1 hairy and enhancer of split-related protein HELT isoform X1

See identical proteins and their annotated locations for XP_008769494.1

UniProtKB/TrEMBL

A6JPP0

Related

ENSRNOP00000014360.5, ENSRNOT00000014360.7

Conserved Domains (2) summary

cd11408
Location:14 → 69

bHLH-O_HELT; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split-related protein HELT and similar proteins

pfam07527
Location:87 → 127

Hairy_orange; Hairy Orange
XM_063275987.1 → XP_063132057.1 hairy and enhancer of split-related protein HELT isoform X2

UniProtKB/TrEMBL

A6JPP0, D4ADJ5