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    Arhgef10l Rho guanine nucleotide exchange factor 10 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684811, updated on 27-Dec-2024

    Summary

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    Symbol
    Arhgef10lprovided by RGD
    Full Name
    Rho guanine nucleotide exchange factor 10 likeprovided by RGD
    Primary source
    RGD:1585585
    See related
    EnsemblRapid:ENSRNOG00000050636 AllianceGenome:RGD:1585585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in SREBP signaling pathway; actin cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.1), Muscle (RPKM 104.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef10l in Genome Data Viewer
    Location:
    5q36
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158075370..158218358, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (152792247..152935255, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159018373..159089383, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479044 Neighboring gene uncharacterized LOC120103019 Neighboring gene uncharacterized LOC120103021 Neighboring gene uncharacterized LOC134487026 Neighboring gene uncharacterized LOC120103020

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. Earp M, et al. PLoS One, 2018. PMID 29979793, Free PMC Article
    2. GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor. Winkler S, et al. Biochem Biophys Res Commun, 2005 Oct 7. PMID 16112081
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10-like protein
    Names
    Rho guanine nucleotide exchange factor (GEF) 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427747.1 → NP_001414676.1  rho guanine nucleotide exchange factor 10-like protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      M0RBM9
      Related
      ENSRNOP00000065550.4, ENSRNOT00000074378.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158075370..158218358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288423.1 → XP_063144493.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      M0RAV6, M0RBM9
      Related
      ENSRNOP00000066667.3, ENSRNOT00000075382.5

    2. XM_039111324.2 → XP_038967252.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

      UniProtKB/TrEMBL
      M0RBM9
      Conserved Domains (3) summary
      cd00160
      Location:276 → 460
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:743 → 1234
      WD40_2; WD40 repeated domain
      pfam19057
      Location:485 → 635
      PH_19; PH domain

    3. XM_039111322.2 → XP_038967250.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      M0RAV6, M0RBM9
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:782 → 1273
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 674
      PH_19; PH domain

    4. XM_063288422.1 → XP_063144492.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      M0RAV6, M0RBM9

    5. XM_063288424.1 → XP_063144494.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLV5, M0RBM9
      Related
      ENSRNOP00000078748.1, ENSRNOT00000108840.2

    6. XM_039111330.2 → XP_038967258.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYN6
      Related
      ENSRNOP00000084703.1, ENSRNOT00000103602.2
      Conserved Domains (3) summary
      cd00160
      Location:98 → 282
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:565 → 1056
      WD40_2; WD40 repeated domain
      pfam19057
      Location:307 → 457
      PH_19; PH domain

    7. XM_063288425.1 → XP_063144495.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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