Stard6 StAR-related lipid transfer domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Stard6provided by RGD
Full Name: StAR-related lipid transfer domain containing 6provided by RGD
Primary source: RGD:1359639
See related: EnsemblRapid:ENSRNOG00000026324 AllianceGenome:RGD:1359639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid binding activity. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 612.2) and Thymus (RPKM 21.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (66365526..66393439)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (64089618..64118528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (68983491..69004868)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

StarD6 might also play a role for neurosteroidogenesis in the hippocampus of aged rats
Title: A comparison of the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing 6 on the brain and testes between young and aged rats.
The StarD6 may not be closely related with DNA repair proteins in the hippocampus after domoic acid-induced excitotoxicity, although the activities of these proteins might be positively affected by excitotoxic stimuli.
Title: Acute responses of DNA repair proteins and StarD6 in rat hippocampus after domoic acid-induced excitotoxicity.
These results suggest that StarD6 may affect the development of Purkinje cells during the first and second postnatal weeks, a known period of thyroid hormone action.
Title: Immunolocalization of steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing proteins in the developing cerebellum of normal and hypothyroid rats.
morphological aspects of StarD6 were significantly different from those of StAR in cultured glial and neuronal cells, as well as the distribution in the normal and epileptic rat hippocampus
Title: Does the StarD6 mark the same as the StAR in the nervous system?
StarD6 might have nuclear roles and contribute to subsequent formation of neuroprotective steroids after excitotoxic brain injury.
Title: The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.
StarD6 might play an important role in lipid sensing of the nervous system
Title: Immunohistochemical detection of StarD6 in the rat nervous system.
StarD6 may play a pivotal role, not only in the spermatogenesis of normal rats, but also in the steroidogenesis of Leydig cells under perinatal hypothyroidism
Title: The changed immunolocalization of START-domain-containing 6 (StarD6) during the development of testes in rat perinatal hypothyroidism.
In situ hybridization showed Stard6 mRNA expression to be germ cell-specific and expressed only during the maturation stages of round and elongated spermatids of adult rat testis.
Title: Expression of the putative sterol binding protein Stard6 gene is male germ cell specific.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 6

Names: STAR-related lipid transfer (START) domain containing protein 6; START domain containing protein 6; StAR-related lipid transfer (START) domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007627.1 → NP_001007628.1 stAR-related lipid transfer protein 6

See identical proteins and their annotated locations for NP_001007628.1

Status: PROVISIONAL

Source sequence(s)

BC078976

UniProtKB/TrEMBL

Q5DNW2, Q6AYN5

Related

ENSRNOP00000002969.5, ENSRNOT00000002969.6

Conserved Domains (1) summary

cl14643
Location:1 → 204

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

66365526..66393439

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096655.2 → XP_038952583.1 stAR-related lipid transfer protein 6 isoform X2

Conserved Domains (1) summary

cl14643
Location:1 → 160

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_008772112.4 → XP_008770334.1 stAR-related lipid transfer protein 6 isoform X1

See identical proteins and their annotated locations for XP_008770334.1

UniProtKB/TrEMBL

Q5DNW2, Q6AYN5

Conserved Domains (1) summary

cl14643
Location:1 → 204

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily