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    Ing3 inhibitor of growth family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312154, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ing3provided by RGD
    Official Full Name
    inhibitor of growth family, member 3provided by RGD
    Primary source
    RGD:1310556
    See related
    EnsemblRapid:ENSRNOG00000005496 AllianceGenome:RGD:1310556
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone H4 acetyltransferase activity and methylated histone binding activity. Predicted to contribute to histone H2A acetyltransferase activity and histone H4 acetyltransferase activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of chromatin and piccolo histone acetyltransferase complex. Used to study hepatocellular carcinoma. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 52.1), Spleen (RPKM 41.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ing3 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (51439218..51469502)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (50477954..50505168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (49017235..49044450)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 12 Neighboring gene cytochrome c oxidase subunit 6C-2-like Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene Wnt family member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. Ahmed HH, et al. Toxicol Mech Methods, 2014 Dec. PMID 25156538
    2. Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling. Wang J, et al. Arch Biochem Biophys, 2014 Nov 15. PMID 25151306
    3. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. Lee WY, et al. Plant J, 2009 May. PMID 19154204
    4. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article
    5. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ING3 bas a role in inducing cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling
      Title: Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112729

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to histone H2A acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K16 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of piccolo histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034107.2 → NP_001029279.1  inhibitor of growth protein 3

      See identical proteins and their annotated locations for NP_001029279.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q498T3
      UniProtKB/TrEMBL
      A0A8I6A977
      Related
      ENSRNOP00000088161.2, ENSRNOT00000104929.2
      Conserved Domains (3) summary
      COG5034
      Location:4 → 413
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:365 → 409
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3 → 102
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      51439218..51469502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236140.4 → XP_006236202.1  inhibitor of growth protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A977
      Conserved Domains (3) summary
      COG5034
      Location:4 → 402
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:354 → 398
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3 → 102
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. XM_006236141.4 → XP_006236203.1  inhibitor of growth protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006236203.1

      UniProtKB/TrEMBL
      A0A8I6A977, A6IE55
      Related
      ENSRNOP00000007476.5, ENSRNOT00000007476.7
      Conserved Domains (2) summary
      cd15585
      Location:341 → 385
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      cd16858
      Location:8 → 74
      ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins

    3. XM_063285972.1 → XP_063142042.1  inhibitor of growth protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A977

    4. XM_039107508.2 → XP_038963436.1  inhibitor of growth protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A977
      Conserved Domains (2) summary
      cd15585
      Location:330 → 374
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      cd16858
      Location:1 → 63
      ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498T3.1 GenPept UniProtKB/Swiss-Prot:Q498T3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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