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    Psma3 proteasome 20S subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psma3provided by RGD
    Official Full Name
    proteasome 20S subunit alpha 3provided by RGD
    Primary source
    RGD:61844
    See related
    EnsemblRapid:ENSRNOG00000007851 AllianceGenome:RGD:61844
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psma3l
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of endopeptidase activity. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in cytoplasm; nucleus; and synapse. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 335.1), Muscle (RPKM 333.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psma3 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (95219714..95239745)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (89483741..89503775)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (93423029..93444223)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene actin related protein 10 Neighboring gene transfer RNA lysine (anticodon CUU) 9 Neighboring gene AT-rich interaction domain 4A Neighboring gene translocase of outer mitochondrial membrane 20 like Neighboring gene translocase of inner mitochondrial membrane 9 Neighboring gene KIAA0586 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and sequencing of component C8 of proteasomes from rat hepatoma cells. Tanaka K, et al. Biochem Biophys Res Commun, 1990 Sep 14. PMID 2403356
    2. Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase. Existence of N-terminal conserved and C-terminal diverged sequences among subunits. Sorimachi H, et al. Eur J Biochem, 1990 Nov 13. PMID 2249692
    3. The NH2-terminal residues of rat liver proteasome (multicatalytic proteinase complex) subunits, C2, C3 and C8, are N alpha-acetylated. Tokunaga F, et al. FEBS Lett, 1990 Apr 24. PMID 2335242
    4. Activity-dependent dynamics and sequestration of proteasomes in dendritic spines. Bingol B, et al. Nature, 2006 Jun 29. PMID 16810255
    5. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. Brehm A, et al. J Clin Invest, 2015 Nov 2. PMID 26524591, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit alpha type-3
    Names
    alpha-7
    macropain subunit C8
    multicatalytic endopeptidase complex subunit C8
    multicatalytic proteinase subunit K
    proteasome (prosome, macropain) subunit, alpha type 3
    proteasome component C8
    proteasome subunit C8
    proteasome subunit K
    proteasome subunit alpha 3
    proteasome subunit alpha-7
    NP_058976.1
    XP_017449548.1
    XP_063117662.1
    XP_063117663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017280.2 → NP_058976.1  proteasome subunit alpha type-3

      See identical proteins and their annotated locations for NP_058976.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081817
      UniProtKB/Swiss-Prot
      P18422
      UniProtKB/TrEMBL
      A6HC06, Q6IE67
      Related
      ENSRNOP00000084525.1, ENSRNOT00000105733.2
      Conserved Domains (1) summary
      cd03751
      Location:5 → 217
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      95219714..95239745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594059.3 → XP_017449548.1  proteasome subunit alpha type-3 isoform X2

      Conserved Domains (1) summary
      cl00467
      Location:1 → 142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. XM_063261593.1 → XP_063117663.1  proteasome subunit alpha type-3 isoform X3

      UniProtKB/TrEMBL
      A6HH67

    3. XM_063261592.1 → XP_063117662.1  proteasome subunit alpha type-3 isoform X1

      UniProtKB/TrEMBL
      Q6IE67
      Related
      ENSRNOP00000010753.5, ENSRNOT00000010753.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18422.3 GenPept UniProtKB/Swiss-Prot:P18422

    Gene LinkOut

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