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    Nsmaf neutral sphingomyelinase activation associated factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsmafprovided by RGD
    Official Full Name
    neutral sphingomyelinase activation associated factorprovided by RGD
    Primary source
    RGD:727868
    See related
    EnsemblRapid:ENSRNOG00000010234 AllianceGenome:RGD:727868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FAN
    Summary
    Enables sphingomyelin phosphodiesterase activator activity. Involved in positive regulation of apoptotic process. Orthologous to human NSMAF (neutral sphingomyelinase activation associated factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 176.6), Spleen (RPKM 146.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsmaf in Genome Data Viewer
    Location:
    5q12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (24315319..24378346, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (19517795..19578773, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (19499111..19560308, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene syndecan binding protein Neighboring gene uncharacterized LOC134478929 Neighboring gene G3BP stress granule assembly factor 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death. O'Brien NW, et al. Circ Res, 2003 Apr 4. PMID 12637370
    2. Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction. Frazziano G, et al. J Cell Physiol, 2011 Oct. PMID 21792922
    3. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Lei X, et al. Biochemistry, 2007 Sep 4. PMID 17685585, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose an integrated signalling pathway for hypoxic pulmonary vasoconstriction which includes nSMase-PKCzeta-NADPH oxidase as a necessary step required for reactive oxygen species production.
      Title: Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction.
    2. These findings indicate that iPLA2beta activation participates in ER stress-induced INS-1 cell apoptosis by promoting ceramide generation via NSMase-catalyzed hydrolysis of sphingomyelins
      Title: The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sphingomyelin phosphodiesterase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of amide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAN
    Names
    factor associated with neutral sphingomyelinase activation
    neutral sphingomyelinase (N-SMase) activation associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181389.3 → NP_852054.2  protein FAN

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1M974, Q7TSY5
      Related
      ENSRNOP00000108097.1, ENSRNOT00000141492.1
      Conserved Domains (4) summary
      cd00200
      Location:625 → 917
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:636 → 673
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:304 → 575
      Beach; Beige/BEACH domain
      cl17171
      Location:192 → 285
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      24315319..24378346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287865.1 → XP_063143935.1  protein FAN isoform X1

      UniProtKB/TrEMBL
      A0A8I6A334

    2. XM_063287867.1 → XP_063143937.1  protein FAN isoform X1

      UniProtKB/TrEMBL
      A0A8I6A334
      Related
      ENSRNOP00000086135.1, ENSRNOT00000107237.2

    3. XM_063287866.1 → XP_063143936.1  protein FAN isoform X1

      UniProtKB/TrEMBL
      A0A8I6A334

    4. XM_039110149.2 → XP_038966077.1  protein FAN isoform X2

      UniProtKB/TrEMBL
      Q7TSY5
      Conserved Domains (4) summary
      sd00039
      Location:637 → 673
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:304 → 575
      Beach; Beige/BEACH domain
      cl17171
      Location:192 → 285
      PH-like; Pleckstrin homology-like domain
      cl29593
      Location:617 → 743
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_039110150.2 → XP_038966078.1  protein FAN isoform X3

      UniProtKB/TrEMBL
      A6JFP4
      Conserved Domains (2) summary
      pfam02138
      Location:304 → 575
      Beach; Beige/BEACH domain
      cl17171
      Location:192 → 285
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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