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    Nsun5 NOP2/Sun RNA methyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsun5provided by RGD
    Official Full Name
    NOP2/Sun RNA methyltransferase 5provided by RGD
    Primary source
    RGD:1309268
    See related
    EnsemblRapid:ENSRNOG00000001450 AllianceGenome:RGD:1309268
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309268
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in several processes, including central nervous system development; rRNA base methylation; and regulation of myelination. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 78.8), Spleen (RPKM 71.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsun5 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26930204..26935887, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21293637..21299319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24341940..24346900, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481281 Neighboring gene uncharacterized LOC120095917 Neighboring gene POM121 transmembrane nucleoporin Neighboring gene tripartite motif-containing 50 Neighboring gene FKBP prolyl isomerase family member 6 Neighboring gene uncharacterized LOC120095916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Janin M, et al. Acta Neuropathol, 2019 Dec. PMID 31428936, Free PMC Article
    2. Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Heissenberger C, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31722427, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    28S rRNA (cytosine-C(5))-methyltransferase
    Names
    NOL1/NOP2/Sun domain family, member 5
    NOP2/Sun RNA methyltransferase family member 5
    NOP2/Sun domain family, member 5
    probable 28S rRNA (cytosine-C(5))-methyltransferase
    putative methyltransferase NSUN5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191593.1 → NP_001178522.1  28S rRNA (cytosine-C(5))-methyltransferase

      See identical proteins and their annotated locations for NP_001178522.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J0D2, G3V660
      Related
      ENSRNOP00000001970.4, ENSRNOT00000001970.9
      Conserved Domains (2) summary
      TIGR00446
      Location:136 → 422
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      cl17173
      Location:217 → 420
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26930204..26935887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089215.2 → XP_038945143.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X3

      Conserved Domains (1) summary
      COG0144
      Location:45 → 422
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    2. XM_063271152.1 → XP_063127222.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X1

    3. XM_063271153.1 → XP_063127223.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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