Il7r interleukin 7 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il7rprovided by RGD
Official Full Name: interleukin 7 receptorprovided by RGD
Primary source: RGD:1309776
See related: EnsemblRapid:ENSRNOG00000065741 AllianceGenome:RGD:1309776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable interleukin-7 receptor activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; interleukin-7-mediated signaling pathway; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and positive regulation of T cell differentiation in thymus. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in external side of plasma membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in colon cancer; lung non-small cell carcinoma; primary immunodeficiency disease; severe combined immunodeficiency; and stomach cancer. Orthologous to human IL7R (interleukin 7 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 222.4), Thymus (RPKM 182.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (60179561..60204937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (58452393..58477757, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2 Unlocalized Scaffold	NW_007906130.1 (21860..53921, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131549 (e-PCR)
- UniSTS:214832

RH139982 (e-PCR)
- UniSTS:222064

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-7 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-7 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106418.1 → NP_001099888.1 interleukin-7 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_001099888.1

Status: PROVISIONAL

Source sequence(s)

CH474048

UniProtKB/TrEMBL

A6KGJ9, D4A3X8

Related

ENSRNOP00000093429.2, ENSRNOT00000113073.2

Conserved Domains (2) summary

pfam18447
Location:32 → 127

FN3_7; Fibronectin type III domain

cl21522
Location:131 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...