Cachd1 cache domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cachd1provided by RGD
Official Full Name: cache domain containing 1provided by RGD
Primary source: RGD:1310770
See related: EnsemblRapid:ENSRNOG00000010514 AllianceGenome:RGD:1310770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310770
Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACHD1 (cache domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 77.4), Lung (RPKM 67.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (120527224..120752685)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (115411833..115637312)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (119596726..119832326)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cachd1 influences both CaV2.2 trafficking and function and can inhibit responses to alpha2delta-1.
Title: The α(2)δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α(2)δ-1.

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General gene information

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Markers

BE120332 (e-PCR)
- UniSTS:247309

AI010254 (e-PCR)
- UniSTS:260635

D5Uwm30 (e-PCR)
- UniSTS:239986

BF405547 (e-PCR)
- UniSTS:247933

fc27g10.x1 (e-PCR)
- UniSTS:203910

AU048588 (e-PCR)
- UniSTS:145038

BE106312 (e-PCR)
- UniSTS:261321

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: VWFA and cache domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191758.1 → NP_001178687.1 VWFA and cache domain-containing protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6A388, A6JRN0

Related

ENSRNOP00000087480.1, ENSRNOT00000119295.2

Conserved Domains (4) summary

cl38916
Location:463 → 503

HK_sensor; Sensor domains of Histidine Kinase receptors

pfam02743
Location:688 → 881

dCache_1; Cache domain

pfam08399
Location:103 → 218

VWA_N; VWA N-terminal

cl00057
Location:227 → 422

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...