Dsel dermatan sulfate epimerase-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dselprovided by RGD
Official Full Name: dermatan sulfate epimerase-likeprovided by RGD
Primary source: RGD:1307724
See related: EnsemblRapid:ENSRNOG00000032307 AllianceGenome:RGD:1307724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307724
Summary: Predicted to enable chondroitin-glucuronate 5-epimerase activity. Predicted to be involved in chondroitin sulfate metabolic process and dermatan sulfate metabolic process. Predicted to be located in membrane. Orthologous to human DSEL (dermatan sulfate epimerase like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 58.5), Brain (RPKM 52.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (194738..200959, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (186413..192592, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (1942384..1948563, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chondroitin-glucuronate 5-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chondroitin-glucuronate 5-epimerase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondroitin sulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dermatan sulfate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dermatan sulfate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dermatan-sulfate epimerase-like protein

XP_006249670.1

EC 5.1.3.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429578.1 → NP_001416507.1 dermatan-sulfate epimerase-like protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6K6R8, D3ZYE3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

194738..200959 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249608.5 → XP_006249670.1 dermatan-sulfate epimerase-like protein isoform X1

Related

ENSRNOP00000111063.1, ENSRNOT00000156385.1

Conserved Domains (1) summary

cl21551
Location:1007 → 1154

Sulfotransfer_1; Sulfotransferase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001305281.1: Suppressed sequence

Description

NM_001305281.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.