Sestd1 SEC14 and spectrin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sestd1provided by RGD
Official Full Name: SEC14 and spectrin domain containing 1provided by RGD
Primary source: RGD:1562244
See related: EnsemblRapid:ENSRNOG00000012603 AllianceGenome:RGD:1562244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562244
Summary: Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Predicted to be involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be located in intermediate filament cytoskeleton. Predicted to be part of calcium channel complex. Orthologous to human SESTD1 (SEC14 and spectrin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 234.7), Brain (RPKM 117.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (82530796..82627960, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (62123590..62220759, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (64037814..64134973, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that SESTD1 may act as a negative regulator of the Rac1-Trio8 signaling pathway to reduce dendritic spine density and lower excitatory synaptic transmission in hippocampal neurons.
Title: The phospholipid-binding protein SESTD1 negatively regulates dendritic spine density by interfering with Rac1-Trio8 signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
NOT enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
NOT enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SEC14 domain and spectrin repeat-containing protein 1

Names: SEC14 and spectrin domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134514.2 → NP_001127986.2 SEC14 domain and spectrin repeat-containing protein 1

See identical proteins and their annotated locations for NP_001127986.2

Status: VALIDATED

Source sequence(s)

BC169110

UniProtKB/TrEMBL

B5DFL9, F7FA26

Related

ENSRNOP00000016837.7, ENSRNOT00000016837.7

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

82530796..82627960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761893.4 → XP_008760115.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_008760115.1

UniProtKB/TrEMBL

B5DFL9, F7FA26

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_008761892.4 → XP_008760114.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_008760114.1

UniProtKB/TrEMBL

B5DFL9, F7FA26

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063283279.1 → XP_063139349.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

B5DFL9, F7FA26
XM_039104496.2 → XP_038960424.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

B5DFL9, F7FA26

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006234404.5 → XP_006234466.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234466.1

UniProtKB/TrEMBL

B5DFL9, F7FA26

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006234402.5 → XP_006234464.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234464.1

UniProtKB/TrEMBL

B5DFL9, F7FA26

Conserved Domains (2) summary

pfam13716
Location:33 → 153

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:273 → 478

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...