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    Cfap300 cilia and flagella associated protein 300 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 654482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap300provided by RGD
    Official Full Name
    cilia and flagella associated protein 300provided by RGD
    Primary source
    RGD:1591894
    See related
    AllianceGenome:RGD:1591894
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytoplasm and motile cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 38. Orthologous to human CFAP300 (cilia and flagella associated protein 300). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 47.9), Lung (RPKM 29.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cfap300 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (13465016..13483679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (5180180..5198840, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (6218391..6236438, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546843 Neighboring gene Yes1 associated transcriptional regulator Neighboring gene centrosomal protein 126 Neighboring gene PMS1 protein homolog 1-like Neighboring gene PMS1 protein homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 300
    Names
    uncharacterized protein C11orf70 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039174.1 → NP_001034263.1  cilia- and flagella-associated protein 300

      See identical proteins and their annotated locations for NP_001034263.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079425
      UniProtKB/Swiss-Prot
      Q68FQ4
      UniProtKB/TrEMBL
      A0A8L2QTY4, A6JN50
      Conserved Domains (1) summary
      pfam14926
      Location:14 → 259
      DUF4498; Domain of unknown function (DUF4498)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      13465016..13483679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242497.5 → XP_006242559.1  cilia- and flagella-associated protein 300 isoform X1

      Conserved Domains (1) summary
      pfam14926
      Location:28 → 236
      DUF4498; Domain of unknown function (DUF4498)

    2. XM_039082123.2 → XP_038938051.1  cilia- and flagella-associated protein 300 isoform X3

      Conserved Domains (1) summary
      pfam14926
      Location:1 → 152
      DUF4498; Domain of unknown function (DUF4498)

    3. XM_039082122.2 → XP_038938050.1  cilia- and flagella-associated protein 300 isoform X2

      Conserved Domains (1) summary
      pfam14926
      Location:28 → 217
      DUF4498; Domain of unknown function (DUF4498)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FQ4.1 GenPept UniProtKB/Swiss-Prot:Q68FQ4

    Gene LinkOut

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