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    Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306460, updated on 9-Dec-2024

    Summary

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    Symbol
    Enpp6provided by RGD
    Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 6provided by RGD
    Primary source
    RGD:1311645
    See related
    EnsemblRapid:ENSRNOG00000009660 AllianceGenome:RGD:1311645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    E-NPP 6
    Summary
    Predicted to enable glycerophosphocholine cholinephosphodiesterase activity and glycerophosphodiester phosphodiesterase activity. Predicted to be involved in choline metabolic process and lipid metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 554.6), Adrenal (RPKM 85.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enpp6 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51898557..52026789, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45165883..45294126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48315500..48437258, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551690 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120097575 Neighboring gene storkhead box 2 Neighboring gene uncharacterized LOC103693959 Neighboring gene uncharacterized LOC102551895 Neighboring gene uncharacterized LOC120097410 Neighboring gene prothymosin alpha like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Morita J, et al. Sci Rep, 2016 Feb 18. PMID 26888014, Free PMC Article
    2. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. Sakagami H, et al. J Biol Chem, 2005 Jun 17. PMID 15788404
    3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycerophosphocholine cholinephosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerophosphocholine cholinephosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerophosphocholine cholinephosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycerophosphodiester phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerophosphodiester phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoric diester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within choline metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in choline metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in choline metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphocholine cholinephosphodiesterase ENPP6
    Names
    E-NPP6
    GPC-Cpde
    NPP-6
    choline-specific glycerophosphodiester phosphodiesterase
    ectonucleotide pyrophosphatase/phosphodiesterase family member 6
    ectonucleotide pyrophosphatase/phosphodiesterase family member 6-like
    NP_001402007.1
    XP_008769481.1
    XP_038950452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415078.1 → NP_001402007.1  glycerophosphocholine cholinephosphodiesterase ENPP6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      B0BND0
      UniProtKB/TrEMBL
      A6JPM2
      Related
      ENSRNOP00000080476.2, ENSRNOT00000111159.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      51898557..52026789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771259.4 → XP_008769481.1  glycerophosphocholine cholinephosphodiesterase ENPP6 isoform X1

      UniProtKB/TrEMBL
      A6JPM3, D3ZRI1
      Conserved Domains (2) summary
      pfam01663
      Location:26 → 357
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:24 → 374
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. XM_039094524.2 → XP_038950452.1  glycerophosphocholine cholinephosphodiesterase ENPP6 isoform X2

      UniProtKB/TrEMBL
      A6JPM3, D3ZRI1
      Conserved Domains (1) summary
      pfam01663
      Location:26 → 332
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107311.1: Suppressed sequence

      Description
      NM_001107311.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BND0.1 GenPept UniProtKB/Swiss-Prot:B0BND0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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