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    Cwc22 CWC22 spliceosome associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cwc22provided by RGD
    Official Full Name
    CWC22 spliceosome associated proteinprovided by RGD
    Primary source
    RGD:1565385
    See related
    EnsemblRapid:ENSRNOG00000012651 AllianceGenome:RGD:1565385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565385
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 93.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cwc22 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (83222400..83271427, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (62815230..62864269, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (64731145..64780127, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385B Neighboring gene uncharacterized LOC134486394 Neighboring gene uncharacterized LOC134486396 Neighboring gene U2 spliceosomal RNA Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Barbosa I, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961380
    2. Structure of a human catalytic step I spliceosome. Zhan X, et al. Science, 2018 Feb 2. PMID 29301961
    3. Structure of the human activated spliceosome in three conformational states. Zhang X, et al. Cell Res, 2018 Mar. PMID 29360106, Free PMC Article
    4. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Bertram K, et al. Nature, 2017 Feb 16. PMID 28076346
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor CWC22 homolog
    Names
    CWC22 homolog, spliceosome-associated protein
    CWC22 spliceosome associated protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399981.1 → NP_001386910.1  pre-mRNA-splicing factor CWC22 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMK0, F1LY38
      Related
      ENSRNOP00000092657.2, ENSRNOT00000118363.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      83222400..83271427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761966.2 → XP_008760188.1  pre-mRNA-splicing factor CWC22 homolog isoform X1

      See identical proteins and their annotated locations for XP_008760188.1

      UniProtKB/TrEMBL
      F1LY38
      Conserved Domains (2) summary
      smart00543
      Location:165 → 346
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      cl02653
      Location:457 → 563
      MA3; MA3 domain

    2. XM_008761965.4 → XP_008760187.1  pre-mRNA-splicing factor CWC22 homolog isoform X1

      See identical proteins and their annotated locations for XP_008760187.1

      UniProtKB/TrEMBL
      F1LY38
      Conserved Domains (2) summary
      smart00543
      Location:165 → 346
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      cl02653
      Location:457 → 563
      MA3; MA3 domain

    3. XM_063284136.1 → XP_063140206.1  pre-mRNA-splicing factor CWC22 homolog isoform X4

      UniProtKB/TrEMBL
      A6HMK0, F1LY38

    4. XM_006234425.5 → XP_006234487.1  pre-mRNA-splicing factor CWC22 homolog isoform X3

      See identical proteins and their annotated locations for XP_006234487.1

      UniProtKB/TrEMBL
      A0A8I6GJW5, F1LY38
      Related
      ENSRNOP00000095427.2, ENSRNOT00000103122.2
      Conserved Domains (3) summary
      smart00543
      Location:164 → 345
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam08648
      Location:13 → 112
      DUF1777; Protein of unknown function (DUF1777)
      cl02653
      Location:456 → 562
      MA3; MA3 domain

    5. XM_008761967.4 → XP_008760189.1  pre-mRNA-splicing factor CWC22 homolog isoform X2

      See identical proteins and their annotated locations for XP_008760189.1

      UniProtKB/TrEMBL
      F1LY38
      Conserved Domains (3) summary
      smart00543
      Location:164 → 345
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam08648
      Location:13 → 112
      DUF1777; Protein of unknown function (DUF1777)
      cl02653
      Location:456 → 562
      MA3; MA3 domain

    6. XM_063284137.1 → XP_063140207.1  pre-mRNA-splicing factor CWC22 homolog isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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