Wrn WRN RecQ like helicase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wrnprovided by RGD
Official Full Name: WRN RecQ like helicaseprovided by RGD
Primary source: RGD:1564788
See related: EnsemblRapid:ENSRNOG00000015440 AllianceGenome:RGD:1564788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564788
Summary: Enables chromatin binding activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and cellular response to gamma radiation. Predicted to act upstream of or within several processes, including determination of adult lifespan; protein localization to nucleolus; and replicative senescence. Predicted to be located in centrosome; chromosome; and nuclear lumen. Predicted to be active in chromosome; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 108.3), Kidney (RPKM 78.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (65466552..65602951)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (58763517..58898604)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (62483773..62619018)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an additional mechanistic explanation for c-Myc-induced DNA damage and senescence
Title: c-Myc accelerates S-phase and requires WRN to avoid replication stress.

Submit: New GeneRIF Correction

General gene information

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Markers

AU047467 (e-PCR)
- UniSTS:110480

RH135009 (e-PCR)
- UniSTS:218286

UniSTS:488917 (e-PCR)
- UniSTS:488917

D16Nkg86 (e-PCR)
- UniSTS:527840

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-flap-structured DNA binding	ISO Inferred from Sequence Orthology more info
enables 8-hydroxy-2'-deoxyguanosine DNA binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables G-quadruplex DNA binding	ISO Inferred from Sequence Orthology more info
enables MutLalpha complex binding	ISO Inferred from Sequence Orthology more info
enables Y-form DNA binding	ISO Inferred from Sequence Orthology more info
enables bubble DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	ISO Inferred from Sequence Orthology more info
enables forked DNA-dependent helicase activity	ISO Inferred from Sequence Orthology more info
enables four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables four-way junction helicase activity	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables telomeric D-loop binding	ISO Inferred from Sequence Orthology more info
enables telomeric G-quadruplex DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in G-quadruplex DNA unwinding	IBA Inferred from Biological aspect of Ancestor more info
involved_in G-quadruplex DNA unwinding	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of strand invasion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth rate	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in response to UV-C	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomeric D-loop disassembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Names: Werner syndrome ATP-dependent helicase; Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like

NP_001414000.1

EC 3.6.4.12

XP_038951018.1

EC 3.6.4.12

XP_063131309.1

EC 3.6.4.12

XP_063131310.1

EC 3.6.4.12

XP_063131311.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427071.1 → NP_001414000.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVT6, F1LTH9

Related

ENSRNOP00000055596.4, ENSRNOT00000058805.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

65466552..65602951

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275239.1 → XP_063131309.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1

UniProtKB/TrEMBL

A6IVT6
XM_063275241.1 → XP_063131311.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X4
XM_063275240.1 → XP_063131310.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X2

UniProtKB/TrEMBL

A0A8I6AI75
XM_039095090.2 → XP_038951018.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X3

Conserved Domains (3) summary

smart00341
Location:468 → 544

HRDC; Helicase and RNase D C-terminal

TIGR00614
Location:11 → 325

recQ_fam; ATP-dependent DNA helicase, RecQ family

pfam14493
Location:573 → 667

HTH_40; Helix-turn-helix domain