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    Echs1 enoyl-CoA hydratase, short chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140547, updated on 9-Dec-2024

    Summary

    Symbol
    Echs1provided by RGD
    Full Name
    enoyl-CoA hydratase, short chain 1provided by RGD
    Primary source
    RGD:69330
    See related
    EnsemblRapid:ENSRNOG00000064647 AllianceGenome:RGD:69330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mECH; mECH1
    Summary
    Enables enoyl-CoA hydratase activity. Involved in fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial short-chain enoyl-CoA hydratase 1 deficiency. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1604.5), Liver (RPKM 1479.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Echs1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204324679..204333506, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194895036..194903863, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212570213..212579040, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline-rich acidic protein 1 Neighboring gene fucose mutarotase Neighboring gene uncharacterized LOC134485198 Neighboring gene polyamine oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    enoyl-CoA hydratase, mitochondrial
    Names
    Enoyl-CoA hydratase, short chain 1, mitochondrial
    SCEH
    enoyl CoA hydratase, short chain, 1, mitochondrial
    enoyl Coenzyme A hydratase, short chain 1
    enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
    enoyl-CoA hydratase 1
    enoyl-CoA hydratase, mitochondrial-like
    mitochondrial short-chain enoyl-coenzyme A hydratase 1
    short-chain enoyl-CoA hydratase
    NP_511178.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_078623.2NP_511178.1  enoyl-CoA hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_511178.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064655
      UniProtKB/Swiss-Prot
      P14604
      UniProtKB/TrEMBL
      A0A8L2QDN1, A6HXG6
      Related
      ENSRNOP00000066388.1, ENSRNOT00000071574.4
      Conserved Domains (1) summary
      cl23717
      Location:32288
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204324679..204333506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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