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    Grk6 G protein-coupled receptor kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59076, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grk6provided by RGD
    Official Full Name
    G protein-coupled receptor kinase 6provided by RGD
    Primary source
    RGD:61986
    See related
    EnsemblRapid:ENSRNOG00000014615 AllianceGenome:RGD:61986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gprk6
    Summary
    Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 344.0), Spleen (RPKM 326.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Grk6 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9182160..9198380, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9177018..9192813, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9705917..9721921, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482675 Neighboring gene drebrin 1 Neighboring gene proline rich 7 (synaptic) Neighboring gene coagulation factor XII Neighboring gene profilin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in membrane  

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 6
    Names
    g protein-coupled receptor kinase GRK6
    NP_001106183.1
    NP_001106184.1
    NP_113845.2
    XP_038951961.1
    XP_063132786.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112712.2NP_001106183.1  G protein-coupled receptor kinase 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      P97548
      Related
      ENSRNOP00000073781.2, ENSRNOT00000079063.3
      Conserved Domains (2) summary
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001112713.1NP_001106184.1  G protein-coupled receptor kinase 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AF040750, EX488847
      UniProtKB/TrEMBL
      F1LNP2, Q792R1
      Related
      ENSRNOP00000050134.4, ENSRNOT00000047958.6
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_031657.4NP_113845.2  G protein-coupled receptor kinase 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      P97549
      Related
      ENSRNOP00000101572.1, ENSRNOT00000171946.1
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9182160..9198380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276716.1XP_063132786.1  G protein-coupled receptor kinase 6 isoform X1

      UniProtKB/TrEMBL
      P97549
    2. XM_039096033.2XP_038951961.1  G protein-coupled receptor kinase 6 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain
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