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    Pgf placental growth factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94203, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pgfprovided by RGD
    Official Full Name
    placental growth factorprovided by RGD
    Primary source
    RGD:619850
    See related
    EnsemblRapid:ENSRNOG00000005650 AllianceGenome:RGD:619850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plgf
    Summary
    Enables identical protein binding activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and sprouting angiogenesis. Located in extracellular space. Used to study congestive heart failure and myocardial infarction. Biomarker of diabetic retinopathy; end stage renal disease; pre-eclampsia; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 20.3), Kidney (RPKM 13.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pgf in Genome Data Viewer
    Location:
    6q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110547165..110557747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104816102..104826685, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108994016..109004598, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene metallothionein 1, pseudogene 4 Neighboring gene eukaryotic translation initiation factor 2B subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93298

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables growth factor activity  
    enables growth factor activity  
    enables growth factor activity  
    enables growth factor activity  
    enables identical protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables vascular endothelial growth factor receptor binding  
    enables vascular endothelial growth factor receptor binding PubMed 
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in animal organ regeneration PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis  
    involved_in cell differentiation  
    involved_in cellular response to hormone stimulus PubMed 
    involved_in female pregnancy PubMed 
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within glycogen metabolic process  
    involved_in induction of positive chemotaxis  
    acts_upstream_of_or_within placenta development  
    involved_in positive chemotaxis  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell proliferation PubMed 
    involved_in positive regulation of mast cell chemotaxis  
    acts_upstream_of_or_within regulation of blood pressure  
    acts_upstream_of_or_within regulation of morphogenesis of a branching structure  
    involved_in response to hypoxia  
    involved_in response to hypoxia PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    involved_in sprouting angiogenesis  
    involved_in sprouting angiogenesis PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053595.2NP_446047.1  placenta growth factor precursor

      See identical proteins and their annotated locations for NP_446047.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087006
      UniProtKB/Swiss-Prot
      Q63434
      UniProtKB/TrEMBL
      A0A8L2Q2Z4, A6JE11
      Related
      ENSRNOP00000007790.6, ENSRNOT00000007790.7
      Conserved Domains (1) summary
      smart00141
      Location:46129
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110547165..110557747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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